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AllergoOncology: Generating a canine anti-cancer IgE against the epidermal growth factor receptor (EGFR): Generating a canine anticancer IgE against the epidermal growth factor receptor

Research output: Contribution to journalLetter

Judit Fazekas-Singer, Josef Singer, Kristina M. Ilieva, Miroslawa Matz, Ina Herrmann, Edzard Spillner, Sophia N. Karagiannis, Erika Jensen-Jarolim

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Early online date7 May 2018
DOIs
Publication statusE-pub ahead of print - 7 May 2018

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King's Authors

Abstract

Anti-cancer immunotherapies currently rely on IgG antibodies. In line with the AllergoOncology concept we provide evidence that tumor-specific IgE, alone or combined with IgG, may be superior to IgG treatment alone. The novel can225IgE-λ was made for future studies in dogs as translational model patients.

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