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[Alloreactive helper T cell responses in kidney transplant patients]. [Chinese]

Research output: Contribution to journalArticle

L Weng, C Lin, P Mason, R Lechler, X Gao

Original languageChinese
Pages (from-to)505 - 507
Number of pages3
JournalZhongguo Yixue Kexueyuan Xuebao / Acta Academiae Medicinae Sinicae
Volume22
Issue number6
Publication statusPublished - 2000

King's Authors

Abstract

OBJECTIVE: To study allo-specific immune responses of CD4+ helper T lymphocytes (Th) in patients with long-term and well-functioning renal grafts. METHODS: Peripheral blood mononuclear cells (PBMC) were collected from 16 patients with long-term (3-15 years) and well-functioning live-related renal grafts. Donor-specific Th precursor (Th-p) frequencies in the PBMC were determined by limiting dilution analysis(LDA). RESULTS: Eight out of the 16 patients showed donor-specific hyporesponsiveness. Donor-specific Th-p from the other 8 patients was susceptible to anti-CD4 inhibition. CONCLUSION: Some of the patients carrying long-term and well-functioning renal grafts had become immunologic tolerant to donor cells. Donor-specific Th-p from patients who did not show donor-specific hyporesponsiveness were of low avidity type.

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