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Alterations in working memory networks in amnestic mild cognitive impairment

Research output: Contribution to journalArticle

Standard

Alterations in working memory networks in amnestic mild cognitive impairment. / Migo, E. M.; Mitterschiffthaler, M.; O'Daly, O.; Dawson, G.R.; Dourish, C.T.; Craig, K.J.; Simmons, A.; Wilcock, G. K.; McCulloch, E.; Jackson, S.H.D.; Kopelman, M.D.; Williams, S.C.R.; Morris, R.G.

In: Aging, Neuropsychology and Cognition, Vol. 22, No. 1, 2014, p. 106-127.

Research output: Contribution to journalArticle

Harvard

Migo, EM, Mitterschiffthaler, M, O'Daly, O, Dawson, GR, Dourish, CT, Craig, KJ, Simmons, A, Wilcock, GK, McCulloch, E, Jackson, SHD, Kopelman, MD, Williams, SCR & Morris, RG 2014, 'Alterations in working memory networks in amnestic mild cognitive impairment', Aging, Neuropsychology and Cognition, vol. 22, no. 1, pp. 106-127. https://doi.org/10.1080/13825585.2014.894958

APA

Migo, E. M., Mitterschiffthaler, M., O'Daly, O., Dawson, G. R., Dourish, C. T., Craig, K. J., Simmons, A., Wilcock, G. K., McCulloch, E., Jackson, S. H. D., Kopelman, M. D., Williams, S. C. R., & Morris, R. G. (2014). Alterations in working memory networks in amnestic mild cognitive impairment. Aging, Neuropsychology and Cognition, 22(1), 106-127. https://doi.org/10.1080/13825585.2014.894958

Vancouver

Migo EM, Mitterschiffthaler M, O'Daly O, Dawson GR, Dourish CT, Craig KJ et al. Alterations in working memory networks in amnestic mild cognitive impairment. Aging, Neuropsychology and Cognition. 2014;22(1):106-127. https://doi.org/10.1080/13825585.2014.894958

Author

Migo, E. M. ; Mitterschiffthaler, M. ; O'Daly, O. ; Dawson, G.R. ; Dourish, C.T. ; Craig, K.J. ; Simmons, A. ; Wilcock, G. K. ; McCulloch, E. ; Jackson, S.H.D. ; Kopelman, M.D. ; Williams, S.C.R. ; Morris, R.G. / Alterations in working memory networks in amnestic mild cognitive impairment. In: Aging, Neuropsychology and Cognition. 2014 ; Vol. 22, No. 1. pp. 106-127.

Bibtex Download

@article{60960e98715a4f00af2efd989aa2acf6,
title = "Alterations in working memory networks in amnestic mild cognitive impairment",
abstract = "Patients with amnestic mild cognitive impairment (aMCI) show preserved or mildly impaired working memory, despite their deficits in episodic memory. We aimed to identify performance and/or neural differences between aMCI patients and matched controls on a standard working memory fMRI task. Neuropsychological assessment demonstrated aMCI impairments in verbal and visual episodic long-term memory, with intact IQ and executive function. Participants completed a standard three-level N-back task where patients were unimpaired. Functional activations in the control group were found in expected areas, including the inferior parietal lobule and dorsolateral prefrontal cortex. Group differences were found in the insula and lingual gyrus and, in a region of interest analysis, in the hippocampus. In all cases, these were caused by an absence of task-related deactivations in the aMCI group. The results are consistent with reports of failure in task-related deacivations in aMCI and could be early indications of pathology.",
keywords = "Acknowledged-BRC, Acknowledged-BRC-13/14",
author = "Migo, {E. M.} and M. Mitterschiffthaler and O. O'Daly and G.R. Dawson and C.T. Dourish and K.J. Craig and A. Simmons and Wilcock, {G. K.} and E. McCulloch and S.H.D. Jackson and M.D. Kopelman and S.C.R. Williams and R.G. Morris",
year = "2014",
doi = "10.1080/13825585.2014.894958",
language = "English",
volume = "22",
pages = "106--127",
journal = "Aging, Neuropsychology and Cognition",
issn = "1382-5585",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Alterations in working memory networks in amnestic mild cognitive impairment

AU - Migo, E. M.

AU - Mitterschiffthaler, M.

AU - O'Daly, O.

AU - Dawson, G.R.

AU - Dourish, C.T.

AU - Craig, K.J.

AU - Simmons, A.

AU - Wilcock, G. K.

AU - McCulloch, E.

AU - Jackson, S.H.D.

AU - Kopelman, M.D.

AU - Williams, S.C.R.

AU - Morris, R.G.

PY - 2014

Y1 - 2014

N2 - Patients with amnestic mild cognitive impairment (aMCI) show preserved or mildly impaired working memory, despite their deficits in episodic memory. We aimed to identify performance and/or neural differences between aMCI patients and matched controls on a standard working memory fMRI task. Neuropsychological assessment demonstrated aMCI impairments in verbal and visual episodic long-term memory, with intact IQ and executive function. Participants completed a standard three-level N-back task where patients were unimpaired. Functional activations in the control group were found in expected areas, including the inferior parietal lobule and dorsolateral prefrontal cortex. Group differences were found in the insula and lingual gyrus and, in a region of interest analysis, in the hippocampus. In all cases, these were caused by an absence of task-related deactivations in the aMCI group. The results are consistent with reports of failure in task-related deacivations in aMCI and could be early indications of pathology.

AB - Patients with amnestic mild cognitive impairment (aMCI) show preserved or mildly impaired working memory, despite their deficits in episodic memory. We aimed to identify performance and/or neural differences between aMCI patients and matched controls on a standard working memory fMRI task. Neuropsychological assessment demonstrated aMCI impairments in verbal and visual episodic long-term memory, with intact IQ and executive function. Participants completed a standard three-level N-back task where patients were unimpaired. Functional activations in the control group were found in expected areas, including the inferior parietal lobule and dorsolateral prefrontal cortex. Group differences were found in the insula and lingual gyrus and, in a region of interest analysis, in the hippocampus. In all cases, these were caused by an absence of task-related deactivations in the aMCI group. The results are consistent with reports of failure in task-related deacivations in aMCI and could be early indications of pathology.

KW - Acknowledged-BRC

KW - Acknowledged-BRC-13/14

U2 - 10.1080/13825585.2014.894958

DO - 10.1080/13825585.2014.894958

M3 - Article

VL - 22

SP - 106

EP - 127

JO - Aging, Neuropsychology and Cognition

JF - Aging, Neuropsychology and Cognition

SN - 1382-5585

IS - 1

ER -

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