TY - JOUR
T1 - Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model
AU - Krueger, Martin Wolfgang
AU - Severi, Stefano
AU - Rhode, Kawal
AU - Genovesi, Simonetta
AU - Weber, Frank Michael
AU - Vincenti, Antonio
AU - Fabbrini, Paolo
AU - Seemann, Gunnar
AU - Razavi, Reza
AU - Doessel, Olaf
PY - 2011/3
Y1 - 2011/3
N2 - Background: The prevalence of atrial fibrillation is increased in patients with end-stage renal disease. Previous studies suggested that extracellular electrolyte alterations caused by hemodialysis (HD) therapy could be proarrhythmic.
Methods: Multiscale models were used for a consequent analysis of the effects of extracellular ion concentration changes on atrial electrophysiology. Simulations were based on measured electrolyte concentrations from patients with end-stage renal disease.
Results: Simulated conduction velocity and effective refractory period are decreased at the end of an HD session, with potassium having the strongest influence. P-wave is prolonged in patients undergoing HD therapy in the simulation as in measurements.
Conclusions: Electrolyte concentration alterations impact atrial electrophysiology from the action potential level to the P-wave and can be proarrhythmic, especially because of induced hypokalemia. Analysis of blood electrolytes enables patient-specific electrophysiology modeling. We are providing a tool to investigate atrial arrhythmias associated with HD therapy, which, in the future, can be used to prevent such complications. (C) 2011 Elsevier Inc. All rights reserved.
AB - Background: The prevalence of atrial fibrillation is increased in patients with end-stage renal disease. Previous studies suggested that extracellular electrolyte alterations caused by hemodialysis (HD) therapy could be proarrhythmic.
Methods: Multiscale models were used for a consequent analysis of the effects of extracellular ion concentration changes on atrial electrophysiology. Simulations were based on measured electrolyte concentrations from patients with end-stage renal disease.
Results: Simulated conduction velocity and effective refractory period are decreased at the end of an HD session, with potassium having the strongest influence. P-wave is prolonged in patients undergoing HD therapy in the simulation as in measurements.
Conclusions: Electrolyte concentration alterations impact atrial electrophysiology from the action potential level to the P-wave and can be proarrhythmic, especially because of induced hypokalemia. Analysis of blood electrolytes enables patient-specific electrophysiology modeling. We are providing a tool to investigate atrial arrhythmias associated with HD therapy, which, in the future, can be used to prevent such complications. (C) 2011 Elsevier Inc. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=79952022026&partnerID=8YFLogxK
U2 - 10.1016/j.jelectrocard.2010.11.016
DO - 10.1016/j.jelectrocard.2010.11.016
M3 - Conference paper
VL - 44
SP - 176
EP - 183
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 2
T2 - 37th International Congress on Electrocardiology
Y2 - 1 June 2010
ER -