Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model

Martin Wolfgang Krueger, Stefano Severi, Kawal Rhode, Simonetta Genovesi, Frank Michael Weber, Antonio Vincenti, Paolo Fabbrini, Gunnar Seemann, Reza Razavi, Olaf Doessel

Research output: Contribution to journalConference paper

28 Citations (Scopus)


Background: The prevalence of atrial fibrillation is increased in patients with end-stage renal disease. Previous studies suggested that extracellular electrolyte alterations caused by hemodialysis (HD) therapy could be proarrhythmic. Methods: Multiscale models were used for a consequent analysis of the effects of extracellular ion concentration changes on atrial electrophysiology. Simulations were based on measured electrolyte concentrations from patients with end-stage renal disease. Results: Simulated conduction velocity and effective refractory period are decreased at the end of an HD session, with potassium having the strongest influence. P-wave is prolonged in patients undergoing HD therapy in the simulation as in measurements. Conclusions: Electrolyte concentration alterations impact atrial electrophysiology from the action potential level to the P-wave and can be proarrhythmic, especially because of induced hypokalemia. Analysis of blood electrolytes enables patient-specific electrophysiology modeling. We are providing a tool to investigate atrial arrhythmias associated with HD therapy, which, in the future, can be used to prevent such complications. (C) 2011 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)176 - 183
Number of pages8
JournalJournal of Electrocardiology
Issue number2
Publication statusPublished - Mar 2011
Event37th International Congress on Electrocardiology - Lund, Sweden
Duration: 1 Jun 2010 → …


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