Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study

Wen-bin Guo; Feng Liu; Zhi-min Xue; Xi-jia Xu; Ren-rong Wu; Chao-qiong Ma; Sarah C. Wooderson; Chang-lian Tan; Xue-li Sun; Jin-dong Chen; Zhe-ning Liu; Chang-qing Xiao; Hua-fu Chen; Jing-ping Zhao

doi:10.1016/j.pnpbp.2012.01.011

Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study

Wen-bin Guo, Feng Liu, Zhi-min Xue, Xi-jia Xu, Ren-rong Wu, Chao-qiong Ma, Sarah C. Wooderson, Chang-lian Tan, Xue-li Sun, Jin-dong Chen, Zhe-ning Liu, Chang-qing Xiao, Hua-fu Chen, Jing-ping Zhao

Research output: Contribution to journal › Literature review › peer-review

161 Citations (Scopus)

Abstract

Background: Patients with treatment-resistant depression (TRD) and those with treatment-response depression (TSD) respond to antidepressants differently and previous studies have commonly reported different brain networks in resistant and nonresistant patients. Using the amplitude of low-frequency fluctuations (ALFF) approach, we explored ALFF values of the brain regions in TRD and TSD patients at resting state to test the hypothesis of the different brain networks in TRD and TSD patients. Methods: Eighteen TRD patients, 17 TSD patients and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. Results: There are widespread differences in ALFF values among TRD patients, TSD patients and healthy subjects throughout the cerebellum, the visual recognition circuit (middle temporal gyrus, middle/inferior occipital gyrus and fusiform), the hate circuit (putamen), the default circuit (ACC and medial frontal gyrus) and the risk/action circuit (inferior frontal gyrus). The differences in brain circuits between the TRD and TSD patients are mainly in the cerebellum, the visual recognition circuit and the default circuit. Conclusions: The affected brain circuits of TRD patients might be partly different from those of TSD patients. (c) 2012 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	153 - 160
Number of pages	8
Journal	Progress in Neuro-Psychopharmacology & Biological Psychiatry
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.pnpbp.2012.01.011
Publication status	Published - 27 Apr 2012

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10.1016/j.pnpbp.2012.01.011

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Guo, W., Liu, F., Xue, Z., Xu, X., Wu, R., Ma, C., Wooderson, S. C., Tan, C., Sun, X., Chen, J., Liu, Z., Xiao, C., Chen, H., & Zhao, J. (2012). Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 37(1), 153 - 160. https://doi.org/10.1016/j.pnpbp.2012.01.011

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title = "Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study",

abstract = "Background: Patients with treatment-resistant depression (TRD) and those with treatment-response depression (TSD) respond to antidepressants differently and previous studies have commonly reported different brain networks in resistant and nonresistant patients. Using the amplitude of low-frequency fluctuations (ALFF) approach, we explored ALFF values of the brain regions in TRD and TSD patients at resting state to test the hypothesis of the different brain networks in TRD and TSD patients. Methods: Eighteen TRD patients, 17 TSD patients and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. Results: There are widespread differences in ALFF values among TRD patients, TSD patients and healthy subjects throughout the cerebellum, the visual recognition circuit (middle temporal gyrus, middle/inferior occipital gyrus and fusiform), the hate circuit (putamen), the default circuit (ACC and medial frontal gyrus) and the risk/action circuit (inferior frontal gyrus). The differences in brain circuits between the TRD and TSD patients are mainly in the cerebellum, the visual recognition circuit and the default circuit. Conclusions: The affected brain circuits of TRD patients might be partly different from those of TSD patients. (c) 2012 Elsevier Inc. All rights reserved.",

author = "Wen-bin Guo and Feng Liu and Zhi-min Xue and Xi-jia Xu and Ren-rong Wu and Chao-qiong Ma and Wooderson, {Sarah C.} and Chang-lian Tan and Xue-li Sun and Jin-dong Chen and Zhe-ning Liu and Chang-qing Xiao and Hua-fu Chen and Jing-ping Zhao",

year = "2012",

month = apr,

day = "27",

doi = "10.1016/j.pnpbp.2012.01.011",

language = "English",

volume = "37",

pages = "153 -- 160",

journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",

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Guo, W, Liu, F, Xue, Z, Xu, X, Wu, R, Ma, C, Wooderson, SC, Tan, C, Sun, X, Chen, J, Liu, Z, Xiao, C, Chen, H & Zhao, J 2012, 'Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study', Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 37, no. 1, pp. 153 - 160. https://doi.org/10.1016/j.pnpbp.2012.01.011

Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study. / Guo, Wen-bin; Liu, Feng; Xue, Zhi-min et al.
In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol. 37, No. 1, 27.04.2012, p. 153 - 160.

Research output: Contribution to journal › Literature review › peer-review

TY - JOUR

T1 - Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study

AU - Guo, Wen-bin

AU - Liu, Feng

AU - Xue, Zhi-min

AU - Xu, Xi-jia

AU - Wu, Ren-rong

AU - Ma, Chao-qiong

AU - Wooderson, Sarah C.

AU - Tan, Chang-lian

AU - Sun, Xue-li

AU - Chen, Jin-dong

AU - Liu, Zhe-ning

AU - Xiao, Chang-qing

AU - Chen, Hua-fu

AU - Zhao, Jing-ping

PY - 2012/4/27

Y1 - 2012/4/27

N2 - Background: Patients with treatment-resistant depression (TRD) and those with treatment-response depression (TSD) respond to antidepressants differently and previous studies have commonly reported different brain networks in resistant and nonresistant patients. Using the amplitude of low-frequency fluctuations (ALFF) approach, we explored ALFF values of the brain regions in TRD and TSD patients at resting state to test the hypothesis of the different brain networks in TRD and TSD patients. Methods: Eighteen TRD patients, 17 TSD patients and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. Results: There are widespread differences in ALFF values among TRD patients, TSD patients and healthy subjects throughout the cerebellum, the visual recognition circuit (middle temporal gyrus, middle/inferior occipital gyrus and fusiform), the hate circuit (putamen), the default circuit (ACC and medial frontal gyrus) and the risk/action circuit (inferior frontal gyrus). The differences in brain circuits between the TRD and TSD patients are mainly in the cerebellum, the visual recognition circuit and the default circuit. Conclusions: The affected brain circuits of TRD patients might be partly different from those of TSD patients. (c) 2012 Elsevier Inc. All rights reserved.

AB - Background: Patients with treatment-resistant depression (TRD) and those with treatment-response depression (TSD) respond to antidepressants differently and previous studies have commonly reported different brain networks in resistant and nonresistant patients. Using the amplitude of low-frequency fluctuations (ALFF) approach, we explored ALFF values of the brain regions in TRD and TSD patients at resting state to test the hypothesis of the different brain networks in TRD and TSD patients. Methods: Eighteen TRD patients, 17 TSD patients and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. Results: There are widespread differences in ALFF values among TRD patients, TSD patients and healthy subjects throughout the cerebellum, the visual recognition circuit (middle temporal gyrus, middle/inferior occipital gyrus and fusiform), the hate circuit (putamen), the default circuit (ACC and medial frontal gyrus) and the risk/action circuit (inferior frontal gyrus). The differences in brain circuits between the TRD and TSD patients are mainly in the cerebellum, the visual recognition circuit and the default circuit. Conclusions: The affected brain circuits of TRD patients might be partly different from those of TSD patients. (c) 2012 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.pnpbp.2012.01.011

DO - 10.1016/j.pnpbp.2012.01.011

M3 - Literature review

VL - 37

SP - 153

EP - 160

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

IS - 1

ER -

Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study

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