Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

David Marlevi; Jorge Mariscal-Harana; Nicholas S Burris; Julio Sotelo; Bram Ruijsink; Myrianthi Hadjicharalambous; Liya Asner; Eva Sammut; Radomir Chabiniok; Sergio Uribe; Reidar Winter; Pablo Lamata; Jordi Alastruey; David Nordsletten

doi:10.1007/s12265-021-10181-1

Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

David Marlevi, Jorge Mariscal-Harana, Nicholas S Burris, Julio Sotelo, Bram Ruijsink, Myrianthi Hadjicharalambous, Liya Asner, Eva Sammut, Radomir Chabiniok, Sergio Uribe, Reidar Winter, Pablo Lamata, Jordi Alastruey, David Nordsletten

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr: [Figure not available: see fulltext.].

Original language	English
Journal	Journal of cardiovascular translational research
Early online date	9 Dec 2021
DOIs	https://doi.org/10.1007/s12265-021-10181-1
Publication status	E-pub ahead of print - 9 Dec 2021

Keywords

4D flow MRI
Aortic hemodynamics
Aortic relative pressure
Aortic stiffness
Dilated cardiomyopathy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12265-021-10181-1

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Marlevi, D., Mariscal-Harana, J., Burris, N. S., Sotelo, J., Ruijsink, B., Hadjicharalambous, M., Asner, L., Sammut, E., Chabiniok, R., Uribe, S., Winter, R., Lamata, P., Alastruey, J., & Nordsletten, D. (2021). Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy. Journal of cardiovascular translational research. https://doi.org/10.1007/s12265-021-10181-1

@article{d4fb22d4f53340f892d250d54f6395f5,

title = "Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy",

abstract = "Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr: [Figure not available: see fulltext.].",

keywords = "4D flow MRI, Aortic hemodynamics, Aortic relative pressure, Aortic stiffness, Dilated cardiomyopathy",

author = "David Marlevi and Jorge Mariscal-Harana and Burris, {Nicholas S} and Julio Sotelo and Bram Ruijsink and Myrianthi Hadjicharalambous and Liya Asner and Eva Sammut and Radomir Chabiniok and Sergio Uribe and Reidar Winter and Pablo Lamata and Jordi Alastruey and David Nordsletten",

note = "Funding Information: This work was funded by the BHF New Horizons program (NH/11/5/29058) and by the Engineering and Physical Sciences Research Council (EP/H046410/1 and EP/N011554/1). The research was supported by the NIHR Biomedical Research Centre (BRC) at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust (GSTT) and King{\textquoteright}s College London, by the Wellcome Trust-EPSRC Centre of Excellence in Medical Engineering (WT 088641/Z/09/Z), and by the Department of Health through NIHR Cardiovascular MedTech Co-operative at GSTT. D.M. was supported by the Wallenberg Foundation scholarship program for postdoctoral studies at the Massachusetts Institute of Technology (MIT) and Broad Institute. D.N. acknowledges funding from Engineering and Physical Sciences Research Council (EP/N011554/1 and EP/R003866/1). P.L. holds a Wellcome Trust Senior Research Fellowship (209450/Z/17/Z) and acknowledges funding from the British Heart Foundation (TG/17/3/33406). J.M.H. was funded by the EPSRC Centre for Medical Engineering at King{\textquoteright}s College London (WT 203148/Z/16/Z), and J.A. also acknowledges funding from the British Heart Foundation (PG/15/104/31913) and the Ministry of Science and Higher Education of the Russian Federation [075–15–2020–926]. R.C. additionally acknowledges the support of Inria-UTSW Medical Center Dallas Associated Team TOFMOD and the Ministry of Health of the Czech Republic (project No. NV19-08–00071). J.S. and S.U. were funded by ANID—Millennium Science Initiative Program—NCN17_129 and ANID FONDECYT #1181057. J.S. also has been supported by CONICYT-FONDECYT Postdoctorado #3170737 and ANID FONDECYT de Iniciaci{\'o}n en Investigaci{\'o}n #11200481. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

day = "9",

doi = "10.1007/s12265-021-10181-1",

language = "English",

journal = "Journal of cardiovascular translational research",

issn = "1937-5387",

publisher = "Springer New York",

}

Marlevi, D, Mariscal-Harana, J, Burris, NS, Sotelo, J, Ruijsink, B , Hadjicharalambous, M , Asner, L , Sammut, E , Chabiniok, R, Uribe, S, Winter, R, Lamata, P , Alastruey, J & Nordsletten, D 2021, 'Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy', Journal of cardiovascular translational research. https://doi.org/10.1007/s12265-021-10181-1

TY - JOUR

T1 - Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

AU - Marlevi, David

AU - Mariscal-Harana, Jorge

AU - Burris, Nicholas S

AU - Sotelo, Julio

AU - Ruijsink, Bram

AU - Hadjicharalambous, Myrianthi

AU - Asner, Liya

AU - Sammut, Eva

AU - Chabiniok, Radomir

AU - Uribe, Sergio

AU - Winter, Reidar

AU - Lamata, Pablo

AU - Alastruey, Jordi

AU - Nordsletten, David

N1 - Funding Information: This work was funded by the BHF New Horizons program (NH/11/5/29058) and by the Engineering and Physical Sciences Research Council (EP/H046410/1 and EP/N011554/1). The research was supported by the NIHR Biomedical Research Centre (BRC) at Guy’s and St Thomas’ NHS Foundation Trust (GSTT) and King’s College London, by the Wellcome Trust-EPSRC Centre of Excellence in Medical Engineering (WT 088641/Z/09/Z), and by the Department of Health through NIHR Cardiovascular MedTech Co-operative at GSTT. D.M. was supported by the Wallenberg Foundation scholarship program for postdoctoral studies at the Massachusetts Institute of Technology (MIT) and Broad Institute. D.N. acknowledges funding from Engineering and Physical Sciences Research Council (EP/N011554/1 and EP/R003866/1). P.L. holds a Wellcome Trust Senior Research Fellowship (209450/Z/17/Z) and acknowledges funding from the British Heart Foundation (TG/17/3/33406). J.M.H. was funded by the EPSRC Centre for Medical Engineering at King’s College London (WT 203148/Z/16/Z), and J.A. also acknowledges funding from the British Heart Foundation (PG/15/104/31913) and the Ministry of Science and Higher Education of the Russian Federation [075–15–2020–926]. R.C. additionally acknowledges the support of Inria-UTSW Medical Center Dallas Associated Team TOFMOD and the Ministry of Health of the Czech Republic (project No. NV19-08–00071). J.S. and S.U. were funded by ANID—Millennium Science Initiative Program—NCN17_129 and ANID FONDECYT #1181057. J.S. also has been supported by CONICYT-FONDECYT Postdoctorado #3170737 and ANID FONDECYT de Iniciación en Investigación #11200481. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12/9

Y1 - 2021/12/9

N2 - Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr: [Figure not available: see fulltext.].

AB - Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr: [Figure not available: see fulltext.].

KW - 4D flow MRI

KW - Aortic hemodynamics

KW - Aortic relative pressure

KW - Aortic stiffness

KW - Dilated cardiomyopathy

UR - http://www.scopus.com/inward/record.url?scp=85128497866&partnerID=8YFLogxK

U2 - 10.1007/s12265-021-10181-1

DO - 10.1007/s12265-021-10181-1

M3 - Article

C2 - 34882286

SN - 1937-5387

JO - Journal of cardiovascular translational research

JF - Journal of cardiovascular translational research

ER -

Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

Abstract

Keywords

UN SDGs

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