King's College London

Research portal

Altering the course of schizophrenia: Progress and perspectives

Research output: Contribution to journalArticle

Mark J. Millan, Annie Andrieux, George Bartzokis, Kristin Cadenhead, Paola Dazzan, Paolo Fusar-Poli, Jürgen Gallinat, Jay Giedd, Dennis R. Grayson, Markus Heinrichs, René Kahn, Marie Odile Krebs, Marion Leboyer, David Lewis, Oscar Marin, Philippe Marin, Andreas Meyer-Lindenberg, Patrick McGorry, Philip McGuire, Michael J. Owen & 7 more Paul Patterson, Akira Sawa, Michael Spedding, Peter Uhlhaas, Flora Vaccarino, Claes Wahlestedt, Daniel Weinberger

Original languageEnglish
Pages (from-to)485-515
Number of pages31
JournalNature Reviews Drug Discovery
Volume15
Issue number7
Early online date4 Mar 2016
DOIs
Publication statusPublished - Jul 2016

Documents

King's Authors

Abstract

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to-and of-this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia suggest that pre-diagnostic pharmacotherapy and psychosocial or cognitive-behavioural interventions can delay or moderate the emergence of psychosis. Of particular interest are 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder. This Review aims to provide a broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454