Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Xianjin Cui; Salome Belo; Dirk Krüger; Yong Yan; Rafael T M de Rosales; Maite Jauregui-Osoro; Haitao Ye; Shi Su; Domokos Mathe; Noémi Kovács; Ildikó Horváth; Mariann Semjeni; Kavitha Sunassee; Krisztian Szigeti; Mark A Green; Philip J Blower

doi:10.1016/j.biomaterials.2014.04.004

Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

Xianjin Cui, Salome Belo, Dirk Krüger, Yong Yan, Rafael T M de Rosales, Maite Jauregui-Osoro, Haitao Ye, Shi Su, Domokos Mathe, Noémi Kovács, Ildikó Horváth, Mariann Semjeni, Kavitha Sunassee, Krisztian Szigeti, Mark A Green, Philip J Blower

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Abstract

Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.

Original language	English
Article number	N/A
Pages (from-to)	5840-5846
Number of pages	7
Journal	Biomaterials
Volume	35
Issue number	22
Early online date	24 Apr 2014
DOIs	https://doi.org/10.1016/j.biomaterials.2014.04.004
Publication status	Published - Jul 2014

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Aluminium hydroxide stabilised MnFe2O4 _CUI_Acc1Apr2014Epub24Apr2014_GOLD VoR (CC BY)Final published version, 1.64 MBLicence: CC BY

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Cui, X., Belo, S., Krüger, D., Yan, Y., de Rosales, R. T. M., Jauregui-Osoro, M., Ye, H., Su, S., Mathe, D., Kovács, N., Horváth, I., Semjeni, M., Sunassee, K., Szigeti, K., Green, M. A., & Blower, P. J. (2014). Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials, 35(22), 5840-5846. [N/A]. https://doi.org/10.1016/j.biomaterials.2014.04.004

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title = "Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging",

abstract = "Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.",

author = "Xianjin Cui and Salome Belo and Dirk Kr{\"u}ger and Yong Yan and {de Rosales}, {Rafael T M} and Maite Jauregui-Osoro and Haitao Ye and Shi Su and Domokos Mathe and No{\'e}mi Kov{\'a}cs and Ildik{\'o} Horv{\'a}th and Mariann Semjeni and Kavitha Sunassee and Krisztian Szigeti and Green, {Mark A} and Blower, {Philip J}",

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Cui, X, Belo, S, Krüger, D, Yan, Y, de Rosales, RTM , Jauregui-Osoro, M, Ye, H, Su, S, Mathe, D, Kovács, N, Horváth, I, Semjeni, M, Sunassee, K, Szigeti, K, Green, MA & Blower, PJ 2014, 'Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging', Biomaterials, vol. 35, no. 22, N/A, pp. 5840-5846. https://doi.org/10.1016/j.biomaterials.2014.04.004

TY - JOUR

T1 - Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

AU - Cui, Xianjin

AU - Belo, Salome

AU - Krüger, Dirk

AU - Yan, Yong

AU - de Rosales, Rafael T M

AU - Jauregui-Osoro, Maite

AU - Ye, Haitao

AU - Su, Shi

AU - Mathe, Domokos

AU - Kovács, Noémi

AU - Horváth, Ildikó

AU - Semjeni, Mariann

AU - Sunassee, Kavitha

AU - Szigeti, Krisztian

AU - Green, Mark A

AU - Blower, Philip J

PY - 2014/7

Y1 - 2014/7

N2 - Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.

AB - Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.

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DO - 10.1016/j.biomaterials.2014.04.004

M3 - Article

C2 - 24768194

SN - 0142-9612

VL - 35

SP - 5840

EP - 5846

JO - Biomaterials

JF - Biomaterials

IS - 22

M1 - N/A

ER -

Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

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