Alzheimer's disease and Down's syndrome: an in vivo MRI study

F. Beacher; E. Daly; A. Simmons; V. Prasher; R. Morris; C. Robinson; S. Lovestone; K. Murphy; D. G. M. Murphy

doi:10.1017/S0033291708004054

Alzheimer's disease and Down's syndrome: an in vivo MRI study

F. Beacher, E. Daly, A. Simmons, V. Prasher, R. Morris, C. Robinson, S. Lovestone, K. Murphy, D. G. M. Murphy

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Background. Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD. Method. We compared whole brain anatomy, as measured by volumetric magnetic resonance imaging (MRI), in DS individuals with and without AD. We also investigated whether volumetric differences Could reliably classify DS individuals according to AD status. We used volumetric MRI and manual tracing to examine regional brain anatomy in 19 DS adults with AD and 39 DS adults without AD. Results. DS individuals with AD had significantly smaller corrected volumes bilaterally of the hippocampus and caudate, and right amygdala and putamen, and a significantly larger corrected volume of left peripheral cerebrospinal fluid (CSF), compared to DS individuals without AD. The volume of the hippocampus and caudate nucleus correctly categorized 92% and 92% respectively of DS individuals Without AD, and 75% and 80%, respectively of DS individuals with AD. Conclusions. DS individuals with AD have significant medial temporal and striatal Volume reductions, and these may provide markers of clinical AD.

Original language	English
Pages (from-to)	675 - 684
Number of pages	10
Journal	Psychological Medicine
Volume	39
Issue number	4
DOIs	https://doi.org/10.1017/S0033291708004054
Publication status	Published - Apr 2009

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title = "Alzheimer's disease and Down's syndrome: an in vivo MRI study",

abstract = "Background. Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD. Method. We compared whole brain anatomy, as measured by volumetric magnetic resonance imaging (MRI), in DS individuals with and without AD. We also investigated whether volumetric differences Could reliably classify DS individuals according to AD status. We used volumetric MRI and manual tracing to examine regional brain anatomy in 19 DS adults with AD and 39 DS adults without AD. Results. DS individuals with AD had significantly smaller corrected volumes bilaterally of the hippocampus and caudate, and right amygdala and putamen, and a significantly larger corrected volume of left peripheral cerebrospinal fluid (CSF), compared to DS individuals without AD. The volume of the hippocampus and caudate nucleus correctly categorized 92% and 92% respectively of DS individuals Without AD, and 75% and 80%, respectively of DS individuals with AD. Conclusions. DS individuals with AD have significant medial temporal and striatal Volume reductions, and these may provide markers of clinical AD.",

author = "F. Beacher and E. Daly and A. Simmons and V. Prasher and R. Morris and C. Robinson and S. Lovestone and K. Murphy and Murphy, {D. G. M.}",

year = "2009",

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doi = "10.1017/S0033291708004054",

language = "English",

volume = "39",

pages = "675 -- 684",

journal = "Psychological Medicine",

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publisher = "Cambridge University Press",

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TY - JOUR

T1 - Alzheimer's disease and Down's syndrome: an in vivo MRI study

AU - Beacher, F.

AU - Daly, E.

AU - Simmons, A.

AU - Prasher, V.

AU - Morris, R.

AU - Robinson, C.

AU - Lovestone, S.

AU - Murphy, K.

AU - Murphy, D. G. M.

PY - 2009/4

Y1 - 2009/4

N2 - Background. Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD. Method. We compared whole brain anatomy, as measured by volumetric magnetic resonance imaging (MRI), in DS individuals with and without AD. We also investigated whether volumetric differences Could reliably classify DS individuals according to AD status. We used volumetric MRI and manual tracing to examine regional brain anatomy in 19 DS adults with AD and 39 DS adults without AD. Results. DS individuals with AD had significantly smaller corrected volumes bilaterally of the hippocampus and caudate, and right amygdala and putamen, and a significantly larger corrected volume of left peripheral cerebrospinal fluid (CSF), compared to DS individuals without AD. The volume of the hippocampus and caudate nucleus correctly categorized 92% and 92% respectively of DS individuals Without AD, and 75% and 80%, respectively of DS individuals with AD. Conclusions. DS individuals with AD have significant medial temporal and striatal Volume reductions, and these may provide markers of clinical AD.

AB - Background. Individuals with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). However, few studies have investigated brain anatomy in DS individuals with AD. Method. We compared whole brain anatomy, as measured by volumetric magnetic resonance imaging (MRI), in DS individuals with and without AD. We also investigated whether volumetric differences Could reliably classify DS individuals according to AD status. We used volumetric MRI and manual tracing to examine regional brain anatomy in 19 DS adults with AD and 39 DS adults without AD. Results. DS individuals with AD had significantly smaller corrected volumes bilaterally of the hippocampus and caudate, and right amygdala and putamen, and a significantly larger corrected volume of left peripheral cerebrospinal fluid (CSF), compared to DS individuals without AD. The volume of the hippocampus and caudate nucleus correctly categorized 92% and 92% respectively of DS individuals Without AD, and 75% and 80%, respectively of DS individuals with AD. Conclusions. DS individuals with AD have significant medial temporal and striatal Volume reductions, and these may provide markers of clinical AD.

U2 - 10.1017/S0033291708004054

DO - 10.1017/S0033291708004054

M3 - Article

SN - 1469-8978

VL - 39

SP - 675

EP - 684

JO - Psychological Medicine

JF - Psychological Medicine

IS - 4

ER -

Alzheimer's disease and Down's syndrome: an in vivo MRI study

Abstract

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