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Alzheimer's disease in women

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)53 - 61
Number of pages9
JournalBest Practice & Research Clinical Obstetrics & Gynaecology
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2009

King's Authors

Abstract

Women have a significantly higher risk of developing Alzheimer's disease (AD) than men. This has contributed to the hypothesis that the menopause may contribute to the cascade of pathological processes leading to AD. Studies into the role of oestrogen therapy (OT) oil the prevention and treatment of AD have led to equivocal findings, In Summary, these Studies have Suggested that OT may protect against AD if it is given to Younger women around the time of the menopause (the 'critical period' hypothesis). However, it may have a negative Or neutral effect if it is prescribed to women after this time. This chapter will discuss some of the putative biological mechanisms that May underlie these effects. (C) 2008 Elsevier Ltd. All rights reserved.

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