TY - JOUR
T1 - Ambulatory urodynamic monitoring assessment of dorsal genital nerve stimulation for suppression of involuntary detrusor contractions following spinal cord injury
T2 - a pilot study
AU - Doherty, Sean P.
AU - Vanhoestenberghe, Anne
AU - Duffell, Lynsey D.
AU - Hamid, Rizwan
AU - Knight, Sarah L.
N1 - Funding Information:
Acknowledgements We thank The INSPIRE Foundation for funding this project.
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to International Spinal Cord Society.
PY - 2020/12
Y1 - 2020/12
N2 - Study design: A prospective interventional pilot study using within-individual comparisons. Objectives: To assess the effect of dorsal genital nerve stimulation (DGNS) on urine-storage parameters in participants with spinal cord injury (SCI) and neurogenic detrusor overactivity (NDO) during natural bladder filling. Setting: The London Spinal Cord Injuries Centre at the Royal National Orthopaedic Hospital, Stanmore, UK. Methods: Ambulatory urodynamic monitoring (AUM) was carried out with and without DGNS, before and after a week of using DGNS at home. DGNS was applied on-demand by four participants with bladder sensation, and both continuously and intermittently by one participant with absent sensation. A Wilcoxon sign-rank test was used to test paired results of changes within an AUM session. Results: Urodynamic outcomes were improved using DGNS. Bladder capacity was increased from 244 ± 59 to 346 ± 61 ml (p = 0.0078), a mean change of 46 ± 25%. Maximum detrusor pressure was decreased from 58 ± 18 to 47 ± 18 cmH2O (p = 0.0156), a change of 17 ± 13%, and average peak detrusor pressure was decreased from 56 ± 16 to 31 ± 128 cmH2O (p = 0.0156), a mean reduction of 50 ± 19%. There was an increase in the number of detrusor contractions from the first involuntary detrusor contraction to a strong desire, urgency or incontinence, from 1.5 ± 1.4 to 4.3 ± 1.7, and an increase in time of 23 ± 22 min. There were no changes in baseline outcomes following home use of DGNS. Conclusions: DGNS may be applied on-demand, intermittently or continuously, to increase bladder capacity, decrease storage pressures and provide extra time. Improvements were made in addition to existing antimuscarinic medication regimes.
AB - Study design: A prospective interventional pilot study using within-individual comparisons. Objectives: To assess the effect of dorsal genital nerve stimulation (DGNS) on urine-storage parameters in participants with spinal cord injury (SCI) and neurogenic detrusor overactivity (NDO) during natural bladder filling. Setting: The London Spinal Cord Injuries Centre at the Royal National Orthopaedic Hospital, Stanmore, UK. Methods: Ambulatory urodynamic monitoring (AUM) was carried out with and without DGNS, before and after a week of using DGNS at home. DGNS was applied on-demand by four participants with bladder sensation, and both continuously and intermittently by one participant with absent sensation. A Wilcoxon sign-rank test was used to test paired results of changes within an AUM session. Results: Urodynamic outcomes were improved using DGNS. Bladder capacity was increased from 244 ± 59 to 346 ± 61 ml (p = 0.0078), a mean change of 46 ± 25%. Maximum detrusor pressure was decreased from 58 ± 18 to 47 ± 18 cmH2O (p = 0.0156), a change of 17 ± 13%, and average peak detrusor pressure was decreased from 56 ± 16 to 31 ± 128 cmH2O (p = 0.0156), a mean reduction of 50 ± 19%. There was an increase in the number of detrusor contractions from the first involuntary detrusor contraction to a strong desire, urgency or incontinence, from 1.5 ± 1.4 to 4.3 ± 1.7, and an increase in time of 23 ± 22 min. There were no changes in baseline outcomes following home use of DGNS. Conclusions: DGNS may be applied on-demand, intermittently or continuously, to increase bladder capacity, decrease storage pressures and provide extra time. Improvements were made in addition to existing antimuscarinic medication regimes.
UR - http://www.scopus.com/inward/record.url?scp=85084867921&partnerID=8YFLogxK
U2 - 10.1038/s41394-020-0279-4
DO - 10.1038/s41394-020-0279-4
M3 - Article
C2 - 32355163
AN - SCOPUS:85084867921
SN - 2058-6124
VL - 6
JO - Spinal Cord Series and Cases
JF - Spinal Cord Series and Cases
IS - 1
M1 - 30
ER -