Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort

Inge Mick; Jim Myers; Paul R A Stokes; David Erritzoe; Alessandro Colasanti; Henrietta Bowden-Jones; Luke Clark; Roger N Gunn; Eugenii A Rabiner; Graham E Searle; Adam D Waldman; Mark C Parkin; Alan D Brailsford; David J Nutt; Anne R Lingford-Hughes

doi:10.1017/S1461145714000704

Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort

Inge Mick, Jim Myers, Paul R A Stokes, David Erritzoe, Alessandro Colasanti, Henrietta Bowden-Jones, Luke Clark, Roger N Gunn, Eugenii A Rabiner, Graham E Searle, Adam D Waldman, Mark C Parkin, Alan D Brailsford, David J Nutt, Anne R Lingford-Hughes

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40 Citations (Scopus)

Abstract

This study aimed to replicate a previous study which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healthy volunteers underwent two [11C]carfentanil PET scans, one before and one 3 h following oral amphetamine administration (0.5 mg/kg). Regional changes in [11C]carfentanil BPND from pre- to post-amphetamine were assessed. The amphetamine challenge led to significant reductions in [11C]carfentanil BPND in the putamen, thalamus, frontal lobe, nucleus accumbens, anterior cingulate, cerebellum and insula cortices, replicating our earlier findings. None of the participants experienced significant euphoria/'high', supporting the use of oral amphetamine to characterize in vivo endogenous opioid release following a pharmacological challenge. [11C]carfentanil PET is able to detect changes in binding following an oral amphetamine challenge that reflects endogenous opioid release and is suitable to characterize the opioid system in neuropsychiatric disorders.

Original language	English
Article number	N/A
Pages (from-to)	1-6
Number of pages	6
Journal	International Journal of Neuropsychopharmacology
Volume	N/A
Issue number	N/A
DOIs	https://doi.org/10.1017/S1461145714000704
Publication status	E-pub ahead of print - 2014

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Mick, I., Myers, J., Stokes, P. R. A., Erritzoe, D., Colasanti, A., Bowden-Jones, H., Clark, L., Gunn, R. N., Rabiner, E. A., Searle, G. E., Waldman, A. D., Parkin, M. C., Brailsford, A. D., Nutt, D. J., & Lingford-Hughes, A. R. (2014). Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort. International Journal of Neuropsychopharmacology , N/A(N/A), 1-6. Article N/A. Advance online publication. https://doi.org/10.1017/S1461145714000704

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title = "Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort",

abstract = "This study aimed to replicate a previous study which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healthy volunteers underwent two [11C]carfentanil PET scans, one before and one 3 h following oral amphetamine administration (0.5 mg/kg). Regional changes in [11C]carfentanil BPND from pre- to post-amphetamine were assessed. The amphetamine challenge led to significant reductions in [11C]carfentanil BPND in the putamen, thalamus, frontal lobe, nucleus accumbens, anterior cingulate, cerebellum and insula cortices, replicating our earlier findings. None of the participants experienced significant euphoria/'high', supporting the use of oral amphetamine to characterize in vivo endogenous opioid release following a pharmacological challenge. [11C]carfentanil PET is able to detect changes in binding following an oral amphetamine challenge that reflects endogenous opioid release and is suitable to characterize the opioid system in neuropsychiatric disorders.",

author = "Inge Mick and Jim Myers and Stokes, {Paul R A} and David Erritzoe and Alessandro Colasanti and Henrietta Bowden-Jones and Luke Clark and Gunn, {Roger N} and Rabiner, {Eugenii A} and Searle, {Graham E} and Waldman, {Adam D} and Parkin, {Mark C} and Brailsford, {Alan D} and Nutt, {David J} and Lingford-Hughes, {Anne R}",

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Mick, I, Myers, J, Stokes, PRA, Erritzoe, D, Colasanti, A, Bowden-Jones, H, Clark, L, Gunn, RN, Rabiner, EA, Searle, GE, Waldman, AD, Parkin, MC , Brailsford, AD, Nutt, DJ & Lingford-Hughes, AR 2014, 'Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort', International Journal of Neuropsychopharmacology , vol. N/A, no. N/A, N/A, pp. 1-6. https://doi.org/10.1017/S1461145714000704

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AU - Mick, Inge

AU - Myers, Jim

AU - Stokes, Paul R A

AU - Erritzoe, David

AU - Colasanti, Alessandro

AU - Bowden-Jones, Henrietta

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AU - Gunn, Roger N

AU - Rabiner, Eugenii A

AU - Searle, Graham E

AU - Waldman, Adam D

AU - Parkin, Mark C

AU - Brailsford, Alan D

AU - Nutt, David J

AU - Lingford-Hughes, Anne R

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ER -

Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: replication in an independent cohort

Abstract

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