Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress

Naama Volk, Julius C. Pape, Mareen Engel, Anthony S. Zannas, Nadia Cattane, Annamaria Cattaneo, Elisabeth B. Binder, Alon Chen

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    64 Citations (Scopus)
    208 Downloads (Pure)

    Abstract

    Summary MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies.
    Original languageEnglish
    Pages (from-to)1882-1891
    Number of pages10
    JournalCell Reports
    Volume17
    Issue number7
    Early online date8 Nov 2016
    DOIs
    Publication statusE-pub ahead of print - 8 Nov 2016

    Keywords

    • amygdala
    • FKBP5
    • microRNA-15a
    • chronic stress
    • anxiety
    • early life stress
    • Ago2
    • stress-related psychopathologies
    • stress adaption
    • childhood trauma

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