Amyloid beta concentrations in older people with Down syndrome and dementia

TY - JOUR

T1 - Amyloid beta concentrations in older people with Down syndrome and dementia

AU - Jones, Emma L.

AU - Hanney, Marisa

AU - Francis, Paul T.

AU - Ballard, Clive G.

PY - 2009/2/20

Y1 - 2009/2/20

N2 - People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (A beta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and A beta 1-40 and A beta 1-42 concentrations were found and nor were A beta 1-40 and A beta 1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon A beta 1-40 or A beta 1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

AB - People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (A beta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and A beta 1-40 and A beta 1-42 concentrations were found and nor were A beta 1-40 and A beta 1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon A beta 1-40 or A beta 1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.neulet.2008.12.030

DO - 10.1016/j.neulet.2008.12.030

M3 - Article

VL - 451

SP - 162

EP - 164

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -