King's College London

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

BIOS Consortium, Brain MEND Consortium, Hop, P. J., Zwamborn, R. A. J., Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., van Rheenen, W., van Vugt, J. J. F. A., Dekker, A. M., Westeneng, H. J., Tazelaar, G. H. P., van Eijk, K. R., Moisse, M., Baird, D., Al Khleifat, A., Iacoangeli, A., Ticozzi, N., Ratti, A. & 32 others, Cooper-Knock, J., Morrison, K. E., Shaw, P. J., Basak, A. N., Chiò, A., Calvo, A., Moglia, C., Canosa, A., Brunetti, M., Grassano, M., Gotkine, M., Lerner, Y., Zabari, M., Vourc'H, P., Corcia, P., Couratier, P., Mora Pardina, J. S., Salas, T., Dion, P., Ross, J. P., Henderson, R. D., Mathers, S., McCombe, P. A., Needham, M., Nicholson, G., Rowe, D. B., Pamphlett, R., Mather, K. A., Sachdev, P. S., Furlong, S., Shaw, C. E. & Al-Chalabi, A., 23 Feb 2022, In: Science Translational Medicine. 14, 633, eabj0264.

Research output: Contribution to journal › Review article › peer-review

Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries

KORA-Study Group, 21 Jan 2022, In: Circulation Research. 130, 2, p. 166-180 15 p.

Research output: Contribution to journal › Article › peer-review

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium, van Rheenen, W., van der Spek, R. A. A., Bakker, M. K., van Vugt, J. J. F. A., Hop, P. J., Zwamborn, R. A. J., de Klein, N., Westra, H. J., Bakker, O. B., Deelen, P., Shireby, G., Hannon, E., Moisse, M., Baird, D., Restuadi, R., Dolzhenko, E. & 34 others, Dekker, A. M., Gawor, K., Westeneng, H. J., Tazelaar, G. H. P., van Eijk, K. R., Kooyman, M., Byrne, R. P., Doherty, M., Heverin, M., Al Khleifat, A., Iacoangeli, A., Shatunov, A., Ticozzi, N., Cooper-Knock, J., Smith, B. N., Gromicho, M., Chandran, S., Pal, S., Morrison, K. E., Shaw, P. J., Hardy, J., Orrell, R. W., Sendtner, M., Meyer, T., Başak, N., van der Kooi, A. J., Ratti, A., Fogh, I., Wood, N. W., Topp, S., Curtis, C. J., Breen, G., Shaw, C. E. & Al-Chalabi, A., Dec 2021, In: Nature genetics. 53, 12, p. 1636-1648 13 p.

Research output: Contribution to journal › Article › peer-review

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

Al Khleifat, A., Iacoangeli, A., Van Vugt, J. J. F. A., Bowles, H., Zwamborn, R. A. J., Moisse, M., Zwamborn, R. A. J., Cooper-Knock, J., Shatunov, A., Jones, A., van Rheenen, W., Opie-Martin, S., Fogh, I., Topp, S., Smith, B., Dobson, R., Shaw, C., Chiò, A., Panades, M. P., Mora, J. S. & 10 others, Shaw, P. J., Landers, J. E., Glass, J. D., Başak, A. N., Hardiman, O., Robberecht, W., Van Damme, P., van den Berg, L. H., Veldink, J. H. & Al-Chalabi, A., 19 Oct 2021, In: NPJ Genomic medicine.

Research output: Contribution to journal › Article › peer-review

SCFD1 expression Quantitative Trait Loci in Amyotrophic Lateral Sclerosis are differentially expressed Short title: SCFD1 expression quantitative loci in ALS

Iacoangeli, A., Fogh, I., Selvackadunco, S., Topp, S., Shatunov, A., van Rheenen, W., Al Khleifat, A., Martin, S., Ratti, A., Chio, A., Dobson, R., Hardiman, O., Shaw, C., van den Berg, L. H., Smith, B., Veldink, J., Breen, G., Troakes, C., Al-Chalabi, A. & Jones, A., 7 Oct 2021, In: Brain Communications.

Research output: Contribution to journal › Article › peer-review

Amyotrophic Lateral Sclerosis and Cerebellum

Kabiljo, R., Iacoangeli, A., Al-Chalabi, A. & Rosenzweig, I., 15 Jul 2022, (Accepted/In press) In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Comparison of Kings clinical staging in multinational ALS cohorts

Balendra, R., Al Khleifat, A., Jones, A., Chiwera, T., Wicks, P., Young, C. A., Shaw, P. J., Turner, M. R., Nigel Leigh, P. & Al-Chalabi, A., 18 Jun 2022, In: Amyotrophic lateral sclerosis & frontotemporal degeneration.

Research output: Contribution to journal › Article › peer-review

Protocol for Rhapsody: a longitudinal observational study examining the feasibility of speech phenotyping for remote assessment of neurodegenerative and psychiatric disorders

Hampsey, E., Meszaros, M., Skirrow, C., Strawbridge, R., Taylor, R. H., Chok, L., Aarsland, D., Al-Chalabi, A., Chaudhuri, R., Weston, J., Fristed, E., Podlewska, A., Awogbemila, O. & Young, A. H., 6 Jun 2022, In: BMJ Open. 12, 6, e061193.

Research output: Contribution to journal › Article › peer-review

GEOexplorer: a webserver for gene expression analysis and visualisation

Iacoangeli, A., Dobson, R. & Al-Chalabi, A., 25 Apr 2022, (Accepted/In press) In: Nucleic Acids Research.

Research output: Contribution to journal › Article › peer-review

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS

Project MinE ALS Sequencing Consortium, NYGC ALS Consortium, Eitan, C., Siany, A., Barkan, E., Olender, T., van Eijk, K. R., Moisse, M., Farhan, S. M. K., Danino, Y. M., Yanowski, E., Marmor-Kollet, H., Rivkin, N., Yacovzada, N. S., Hung, S. T., Cooper-Knock, J., Yu, C. H., Louis, C., Masters, S. L., Kenna, K. P. & 26 others, van der Spek, R. A. A., Sproviero, W., Al Khleifat, A., Iacoangeli, A., Shatunov, A., Jones, A. R., Elbaz-Alon, Y., Cohen, Y., Chapnik, E., Rothschild, D., Weissbrod, O., Beck, G., Ainbinder, E., Ben-Dor, S., Werneburg, S., Schafer, D. P., Brown, R. H., Shaw, P. J., Van Damme, P., van den Berg, L. H., Phatnani, H., Segal, E., Ichida, J. K., Al-Chalabi, A., Veldink, J. H. & Hornstein, E., 1 Apr 2022, In: Nature Neuroscience. 25, 4, p. 433-445 13 p.

Research output: Contribution to journal › Article › peer-review

Impaired connectivity within neuromodulatory networks in multiple sclerosis and clinical implications

Carotenuto, A., Wilson, H., Giordano, B., Caminiti, S. P., Chappell, Z., Williams, S. C. R., Hammers, A., Silber, E., Brex, P. & Politis, M., 1 Jul 2020, In: Journal of Neurology. 267, 7, p. 2042-2053 12 p.

Research output: Contribution to journal › Article › peer-review

Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature

TONiC study group, Mar 2020, In: Journal of Neurology. 267, 3, p. 607-615 9 p.

Research output: Contribution to journal › Article › peer-review

Neuroimaging in Lewy body dementia

Yousaf, T., Dervenoulas, G., Valkimadi, P-E. & Politis, M., 14 May 2018, (E-pub ahead of print) In: Journal of Neurology. p. 1-26

Research output: Contribution to journal › Review article › peer-review

Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study

Tavazzi, E., Bergsland, N., Cattaneo, D., Gervasoni, E., Lagana', M. M., Dipasquale, O., Grosso, C., Saibene, F. L., Baglio, F. & Rovaris, M., 2018, In: Journal of Neurology.

Research output: Contribution to journal › Article › peer-review

Macdonald Critchley (1900–1997)

Sandrone, S. & van Gijn, J., 21 Nov 2017, (Accepted/In press) In: Journal of Neurology. p. 1-2 2 p.

Research output: Contribution to journal › Article › peer-review