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An agent-based model of molecular aggregation at the cell membrane

Research output: Contribution to journalArticle

Griffié Juliette, Ruby Peters, Dylan M. Owen

Original languageEnglish
Article numbere0226825
JournalPLoS ONE
Volume15
Issue number2
DOIs
Publication statusPublished - 1 Jan 2020

King's Authors

Research Groups

  • King's College London

Abstract

Molecular clustering at the plasma membrane has long been identified as a key process and is associated with regulating signalling pathways across cell types. Recent advances in microscopy, in particular the rise of super-resolution, have allowed the experimental observation of nanoscale molecular clusters in the plasma membrane. However, modelling approaches capable of recapitulating these observations are in their infancy, partly because of the extremely complex array of biophysical factors which influence molecular distributions and dynamics in the plasma membrane. We propose here a highly abstracted approach: an agent-based model dedicated to the study of molecular aggregation at the plasma membrane. We show that when molecules are modelled as though they can act (diffuse) in a manner which is influenced by their molecular neighbourhood, many of the distributions observed in cells can be recapitulated, even though such sensing and response is not possible for real membrane molecules. As such, agent-based offers a unique platform which may lead to a new understanding of how molecular clustering in extremely complex molecular environments can be abstracted, simulated and interpreted using simple rules.

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