An alternative mechanism for long-term memory formation

Kasia Radwanska; Karl Peter Giese

doi:10.1007/978-3-319-24364-1_5

An alternative mechanism for long-term memory formation

Kasia Radwanska^*, Karl Peter Giese

^*Corresponding author for this work

Basic and Clinical Neuroscience

Head Nencki Institute of Experimental Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Long-term memory (LTM) formation has been linked with functional strengthening of existing synapses as well as other processes including de novo synaptogenesis. However, it is unclear whether synaptogenesis can contribute to LTM formation. Using alpha-calcium/calmodulin kinase II autophosphorylationdefi cient (T286A) mutants, we demonstrate that when functional strengthening is severely impaired contextual LTM formation is linked with training-induced PSD95 upregulation followed by persistent generation of multiinnervated spines (MIS), a type of synapse that is characterized by several presynaptic terminals contacting the same postsynaptic spine. In the chapter, the molecular processes involved in generation of MIS and properties of MIS-dependent memory will be discussed.

Original language	English
Title of host publication	Novel Mechanisms of Memory
Publisher	Springer International Publishing Switzerland
Pages	89-98
Number of pages	10
ISBN (Electronic)	9783319243641
ISBN (Print)	9783319243627
DOIs	https://doi.org/10.1007/978-3-319-24364-1_5
Publication status	Published - 1 Jan 2015

Keywords

Fear memory
Hippocampus
Multiinnervated spines
PSD-95
αCaMKII autophosphorylation

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10.1007/978-3-319-24364-1_5

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AB - Long-term memory (LTM) formation has been linked with functional strengthening of existing synapses as well as other processes including de novo synaptogenesis. However, it is unclear whether synaptogenesis can contribute to LTM formation. Using alpha-calcium/calmodulin kinase II autophosphorylationdefi cient (T286A) mutants, we demonstrate that when functional strengthening is severely impaired contextual LTM formation is linked with training-induced PSD95 upregulation followed by persistent generation of multiinnervated spines (MIS), a type of synapse that is characterized by several presynaptic terminals contacting the same postsynaptic spine. In the chapter, the molecular processes involved in generation of MIS and properties of MIS-dependent memory will be discussed.

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KW - Hippocampus

KW - Multiinnervated spines

KW - PSD-95

KW - αCaMKII autophosphorylation

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BT - Novel Mechanisms of Memory

PB - Springer International Publishing Switzerland

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An alternative mechanism for long-term memory formation

Abstract

Keywords

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