An artificial organosilicon receptor

Vincenzo Abbate; Alan R. Bassindale; Kurt F. Brandstadt; Peter G. Taylor

doi:10.1039/C2PY20135F

An artificial organosilicon receptor

Vincenzo Abbate, Alan R. Bassindale, Kurt F. Brandstadt, Peter G. Taylor

Open University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A biomimicking approach for the selective capture of dimethylcyclosiloxanes was developed. Inclusion complexes between cyclodextrins (CDs) and cyclosiloxanes were isolated and subsequently treated with toluene-2,4-diisocyanate (TDI) in DMSO to afford molecularly imprinted cyclodextrin (MICD) polymers. Following removal of the siloxane-based templates, the imprinted biomimetic polymers were characterized via scanning electron microscopy (SEM), cross-polarization magic angle spinning (CP-MAS) NMR and elemental analysis. Substrate affinity and selectivity were evaluated via equilibrium batch-rebinding assays and quantitative gas-chromatographic analysis. The imprinting effect was assessed by comparing the binding of the synthetic receptors with blank (non-imprinted) polymers. Adsorption isotherms were measured and data fitted using several mathematical models and the dissociation constants (Kd) and the binding site densities (Bmax) were calculated. The study is believed to have delivered the first case of an artificial receptor for an organosilicon substrate, opening a new way for separation and purification in silicon chemistry.

Original language	English
Pages (from-to)	2018-2027
Journal	Polymer Chemistry
Volume	3
Issue number	8
DOIs	https://doi.org/10.1039/C2PY20135F
Publication status	Published - 2012

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title = "An artificial organosilicon receptor",

abstract = "A biomimicking approach for the selective capture of dimethylcyclosiloxanes was developed. Inclusion complexes between cyclodextrins (CDs) and cyclosiloxanes were isolated and subsequently treated with toluene-2,4-diisocyanate (TDI) in DMSO to afford molecularly imprinted cyclodextrin (MICD) polymers. Following removal of the siloxane-based templates, the imprinted biomimetic polymers were characterized via scanning electron microscopy (SEM), cross-polarization magic angle spinning (CP-MAS) NMR and elemental analysis. Substrate affinity and selectivity were evaluated via equilibrium batch-rebinding assays and quantitative gas-chromatographic analysis. The imprinting effect was assessed by comparing the binding of the synthetic receptors with blank (non-imprinted) polymers. Adsorption isotherms were measured and data fitted using several mathematical models and the dissociation constants (Kd) and the binding site densities (Bmax) were calculated. The study is believed to have delivered the first case of an artificial receptor for an organosilicon substrate, opening a new way for separation and purification in silicon chemistry.",

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doi = "10.1039/C2PY20135F",

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journal = "Polymer Chemistry",

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T1 - An artificial organosilicon receptor

AU - Abbate, Vincenzo

AU - Bassindale, Alan R.

AU - Brandstadt, Kurt F.

AU - Taylor, Peter G.

PY - 2012

Y1 - 2012

N2 - A biomimicking approach for the selective capture of dimethylcyclosiloxanes was developed. Inclusion complexes between cyclodextrins (CDs) and cyclosiloxanes were isolated and subsequently treated with toluene-2,4-diisocyanate (TDI) in DMSO to afford molecularly imprinted cyclodextrin (MICD) polymers. Following removal of the siloxane-based templates, the imprinted biomimetic polymers were characterized via scanning electron microscopy (SEM), cross-polarization magic angle spinning (CP-MAS) NMR and elemental analysis. Substrate affinity and selectivity were evaluated via equilibrium batch-rebinding assays and quantitative gas-chromatographic analysis. The imprinting effect was assessed by comparing the binding of the synthetic receptors with blank (non-imprinted) polymers. Adsorption isotherms were measured and data fitted using several mathematical models and the dissociation constants (Kd) and the binding site densities (Bmax) were calculated. The study is believed to have delivered the first case of an artificial receptor for an organosilicon substrate, opening a new way for separation and purification in silicon chemistry.

AB - A biomimicking approach for the selective capture of dimethylcyclosiloxanes was developed. Inclusion complexes between cyclodextrins (CDs) and cyclosiloxanes were isolated and subsequently treated with toluene-2,4-diisocyanate (TDI) in DMSO to afford molecularly imprinted cyclodextrin (MICD) polymers. Following removal of the siloxane-based templates, the imprinted biomimetic polymers were characterized via scanning electron microscopy (SEM), cross-polarization magic angle spinning (CP-MAS) NMR and elemental analysis. Substrate affinity and selectivity were evaluated via equilibrium batch-rebinding assays and quantitative gas-chromatographic analysis. The imprinting effect was assessed by comparing the binding of the synthetic receptors with blank (non-imprinted) polymers. Adsorption isotherms were measured and data fitted using several mathematical models and the dissociation constants (Kd) and the binding site densities (Bmax) were calculated. The study is believed to have delivered the first case of an artificial receptor for an organosilicon substrate, opening a new way for separation and purification in silicon chemistry.

U2 - 10.1039/C2PY20135F

DO - 10.1039/C2PY20135F

M3 - Article

SN - 1759-9954

VL - 3

SP - 2018

EP - 2027

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 8

ER -

An artificial organosilicon receptor

Abstract

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