King's College London

Research portal

An atlas of human metabolism

Research output: Contribution to journalArticlepeer-review

Jonathan L. Robinson, Pınar Kocabaş, Hao Wang, Pierre Etienne Cholley, Daniel Cook, Avlant Nilsson, Mihail Anton, Raphael Ferreira, Iván Domenzain, Virinchi Billa, Angelo Limeta, Alex Hedin, Johan Gustafsson, Eduard J. Kerkhoven, L. Thomas Svensson, Bernhard O. Palsson, Adil Mardinoglu, Lena Hansson, Mathias Uhlén, Jens Nielsen

Original languageEnglish
Article numbereaaz1482
JournalScience Signaling
Issue number624
Published24 Mar 2020

Bibliographical note

Funding Information: Research reported in this publication was supported by funding from the Knut and Alice Wallenberg Foundation, the National Cancer Institute of the NIH under award number F32CA220848 (J.L.R.), the Novo Nordisk Foundation (grant no. NNF10CC1016517), and the European Union?s Horizon 2020 research and innovation program under grant agreement no. 720824 (I.D.). Publisher Copyright: Copyright © 2020 The Authors, some rights reserved.

King's Authors


Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We therefore integrated and extensively curated the most recent human metabolic models to construct a consensus GEM, Human1. We demonstrated the versatility of Human1 through the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic, and kinetic data. We also present an accompanying web portal, Metabolic Atlas (, which facilitates further exploration and visualization of Human1 content. Human1 was created using a version-controlled, open-source model development framework to enable community-driven curation and refinement. This framework allows Human1 to be an evolving shared resource for future studies of human health and disease.

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454