An atlas of the protein-coding genes in the human, pig, and mouse brain

Evelina Sjöstedt; Wen Zhong; Linn Fagerberg; Max Karlsson; Nicholas Mitsios; Csaba Adori; Per Oksvold; Fredrik Edfors; Agnieszka Limiszewska; Feria Hikmet; Jinrong Huang; Yutao Du; Lin Lin; Zhanying Dong; Ling Yang; Xin Liu; Hui Jiang; Xun Xu; Jian Wang; Huanming Yang; Lars Bolund; Adil Mardinoglu; Cheng Zhang; Kalle von Feilitzen; Cecilia Lindskog; Fredrik Pontén; Yonglun Luo; Tomas Hökfelt; Mathias Uhlén; Jan Mulder

doi:10.1126/science.aay5947

An atlas of the protein-coding genes in the human, pig, and mouse brain

Evelina Sjöstedt, Wen Zhong, Linn Fagerberg, Max Karlsson, Nicholas Mitsios, Csaba Adori, Per Oksvold, Fredrik Edfors, Agnieszka Limiszewska, Feria Hikmet, Jinrong Huang, Yutao Du, Lin Lin, Zhanying Dong, Ling Yang, Xin Liu, Hui Jiang, Xun Xu, Jian Wang, Huanming YangLars Bolund, Adil Mardinoglu, Cheng Zhang, Kalle von Feilitzen, Cecilia Lindskog, Fredrik Pontén, Yonglun Luo, Tomas Hökfelt, Mathias Uhlén, Jan Mulder

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619 Citations (Scopus)

Abstract

The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.

Original language	English
Journal	Science (New York, N.Y.)
Volume	367
Issue number	6482
DOIs	https://doi.org/10.1126/science.aay5947
Publication status	Published - 6 Mar 2020

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Sjöstedt, E., Zhong, W., Fagerberg, L., Karlsson, M., Mitsios, N., Adori, C., Oksvold, P., Edfors, F., Limiszewska, A., Hikmet, F., Huang, J., Du, Y., Lin, L., Dong, Z., Yang, L., Liu, X., Jiang, H., Xu, X., Wang, J., ... Mulder, J. (2020). An atlas of the protein-coding genes in the human, pig, and mouse brain. Science (New York, N.Y.), 367(6482). https://doi.org/10.1126/science.aay5947

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title = "An atlas of the protein-coding genes in the human, pig, and mouse brain",

abstract = "The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.",

author = "Evelina Sj{\"o}stedt and Wen Zhong and Linn Fagerberg and Max Karlsson and Nicholas Mitsios and Csaba Adori and Per Oksvold and Fredrik Edfors and Agnieszka Limiszewska and Feria Hikmet and Jinrong Huang and Yutao Du and Lin Lin and Zhanying Dong and Ling Yang and Xin Liu and Hui Jiang and Xun Xu and Jian Wang and Huanming Yang and Lars Bolund and Adil Mardinoglu and Cheng Zhang and {von Feilitzen}, Kalle and Cecilia Lindskog and Fredrik Pont{\'e}n and Yonglun Luo and Tomas H{\"o}kfelt and Mathias Uhl{\'e}n and Jan Mulder",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

year = "2020",

month = mar,

day = "6",

doi = "10.1126/science.aay5947",

language = "English",

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Sjöstedt, E, Zhong, W, Fagerberg, L, Karlsson, M, Mitsios, N, Adori, C, Oksvold, P, Edfors, F, Limiszewska, A, Hikmet, F, Huang, J, Du, Y, Lin, L, Dong, Z, Yang, L, Liu, X, Jiang, H, Xu, X, Wang, J, Yang, H, Bolund, L, Mardinoglu, A , Zhang, C, von Feilitzen, K, Lindskog, C, Pontén, F, Luo, Y, Hökfelt, T, Uhlén, M & Mulder, J 2020, 'An atlas of the protein-coding genes in the human, pig, and mouse brain', Science (New York, N.Y.), vol. 367, no. 6482. https://doi.org/10.1126/science.aay5947

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AU - Sjöstedt, Evelina

AU - Zhong, Wen

AU - Fagerberg, Linn

AU - Karlsson, Max

AU - Mitsios, Nicholas

AU - Adori, Csaba

AU - Oksvold, Per

AU - Edfors, Fredrik

AU - Limiszewska, Agnieszka

AU - Hikmet, Feria

AU - Huang, Jinrong

AU - Du, Yutao

AU - Lin, Lin

AU - Dong, Zhanying

AU - Yang, Ling

AU - Liu, Xin

AU - Jiang, Hui

AU - Xu, Xun

AU - Wang, Jian

AU - Yang, Huanming

AU - Bolund, Lars

AU - Mardinoglu, Adil

AU - Zhang, Cheng

AU - von Feilitzen, Kalle

AU - Lindskog, Cecilia

AU - Pontén, Fredrik

AU - Luo, Yonglun

AU - Hökfelt, Tomas

AU - Uhlén, Mathias

AU - Mulder, Jan

PY - 2020/3/6

Y1 - 2020/3/6

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AB - The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.

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SN - 1095-9203

VL - 367

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

IS - 6482

ER -

An atlas of the protein-coding genes in the human, pig, and mouse brain

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