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An audit of external trigeminal nerve stimulation (eTNS) in epilepsy

Research output: Contribution to journalArticle

Seán J. Slaght, Lina Nashef

Original languageEnglish
Early online date12 Sep 2017
StateE-pub ahead of print - 12 Sep 2017

King's Authors


Purpose: External trigeminal nerve stimulation (eTNS) is a non-invasive neurostimulation treatment for drug refractory epilepsy. There is limited published data on the efficacy of eTNS and none relating to quality of life, mood or effect on sleep quality.

Methods: We audited its use in 42 patients with drug refractory epilepsy at a tertiary centre. Data was collected on seizure frequency, quality of life, mood and sleep quality before and after initiating treatment.

Results: 45% of patients continued to use eTNS at the end of the audit period. We observed a significant improvement in both quality of life and mood in those without intellectual disabilities. A decrease in seizures (−11.0%, min −60, max +65) was observed though this did not reach statistical significance with the relatively small numbers available for analysis.

Conclusion: Further controlled studies are required to confirm the efficacy of eTNS. However, as it is non-invasive, flexible and safe eTNS can be considered as an option in patients with drug refractory epilepsy.

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