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An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

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An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. / Roubroeks, Janou A.Y.; Smith, Adam R.; Smith, Rebecca G.; Pishva, Ehsan; Ibrahim, Zina; Sattlecker, Martina; Hannon, Eilis J.; Kłoszewska, Iwona; Mecocci, Patrizia; Soininen, Hilkka; Tsolaki, Magda; Vellas, Bruno; Wahlund, Lars Olof; Aarsland, Dag; Proitsi, Petroula; Hodges, Angela; Lovestone, Simon; Newhouse, Stephen J.; Dobson, Richard J.B.; Mill, Jonathan; van den Hove, Daniël L.A.; Lunnon, Katie.

In: Neurobiology of Aging, Vol. 95, 11.2020, p. 26-45.

Research output: Contribution to journalArticle

Harvard

Roubroeks, JAY, Smith, AR, Smith, RG, Pishva, E, Ibrahim, Z, Sattlecker, M, Hannon, EJ, Kłoszewska, I, Mecocci, P, Soininen, H, Tsolaki, M, Vellas, B, Wahlund, LO, Aarsland, D, Proitsi, P, Hodges, A, Lovestone, S, Newhouse, SJ, Dobson, RJB, Mill, J, van den Hove, DLA & Lunnon, K 2020, 'An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene', Neurobiology of Aging, vol. 95, pp. 26-45. https://doi.org/10.1016/j.neurobiolaging.2020.06.023

APA

Roubroeks, J. A. Y., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., ... Lunnon, K. (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiology of Aging, 95, 26-45. https://doi.org/10.1016/j.neurobiolaging.2020.06.023

Vancouver

Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M et al. An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiology of Aging. 2020 Nov;95:26-45. https://doi.org/10.1016/j.neurobiolaging.2020.06.023

Author

Roubroeks, Janou A.Y. ; Smith, Adam R. ; Smith, Rebecca G. ; Pishva, Ehsan ; Ibrahim, Zina ; Sattlecker, Martina ; Hannon, Eilis J. ; Kłoszewska, Iwona ; Mecocci, Patrizia ; Soininen, Hilkka ; Tsolaki, Magda ; Vellas, Bruno ; Wahlund, Lars Olof ; Aarsland, Dag ; Proitsi, Petroula ; Hodges, Angela ; Lovestone, Simon ; Newhouse, Stephen J. ; Dobson, Richard J.B. ; Mill, Jonathan ; van den Hove, Daniël L.A. ; Lunnon, Katie. / An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. In: Neurobiology of Aging. 2020 ; Vol. 95. pp. 26-45.

Bibtex Download

@article{ee53a28e256d4f82aba6024e34a136f0,
title = "An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene",
abstract = "A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNeuroMed study, which included 89 nondemented controls, 86 patients with Alzheimer's disease, and 109 individuals with mild cognitive impairment, including 38 individuals who progressed to Alzheimer's disease within 1 year. We identified significant differentially methylated regions, including 12 adjacent hypermethylated probes in the HOXB6 gene in Alzheimer's disease, which we validated using pyrosequencing. Using weighted gene correlation network analysis, we identified comethylated modules of genes that were associated with key variables such as APOE genotype and diagnosis. In summary, this study represents the first large-scale epigenome-wide association study of Alzheimer's disease and mild cognitive impairment using blood. We highlight the differences in various loci and pathways in early disease, suggesting that these patterns relate to cognitive decline at an early stage.",
keywords = "Alzheimer's disease (AD), Biomarker, Blood, DNA methylation, HOXB6, Mild cognitive impairment (MCI)",
author = "Roubroeks, {Janou A.Y.} and Smith, {Adam R.} and Smith, {Rebecca G.} and Ehsan Pishva and Zina Ibrahim and Martina Sattlecker and Hannon, {Eilis J.} and Iwona Kłoszewska and Patrizia Mecocci and Hilkka Soininen and Magda Tsolaki and Bruno Vellas and Wahlund, {Lars Olof} and Dag Aarsland and Petroula Proitsi and Angela Hodges and Simon Lovestone and Newhouse, {Stephen J.} and Dobson, {Richard J.B.} and Jonathan Mill and {van den Hove}, {Dani{\"e}l L.A.} and Katie Lunnon",
year = "2020",
month = "11",
doi = "10.1016/j.neurobiolaging.2020.06.023",
language = "English",
volume = "95",
pages = "26--45",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier B.V.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

AU - Roubroeks, Janou A.Y.

AU - Smith, Adam R.

AU - Smith, Rebecca G.

AU - Pishva, Ehsan

AU - Ibrahim, Zina

AU - Sattlecker, Martina

AU - Hannon, Eilis J.

AU - Kłoszewska, Iwona

AU - Mecocci, Patrizia

AU - Soininen, Hilkka

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Wahlund, Lars Olof

AU - Aarsland, Dag

AU - Proitsi, Petroula

AU - Hodges, Angela

AU - Lovestone, Simon

AU - Newhouse, Stephen J.

AU - Dobson, Richard J.B.

AU - Mill, Jonathan

AU - van den Hove, Daniël L.A.

AU - Lunnon, Katie

PY - 2020/11

Y1 - 2020/11

N2 - A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNeuroMed study, which included 89 nondemented controls, 86 patients with Alzheimer's disease, and 109 individuals with mild cognitive impairment, including 38 individuals who progressed to Alzheimer's disease within 1 year. We identified significant differentially methylated regions, including 12 adjacent hypermethylated probes in the HOXB6 gene in Alzheimer's disease, which we validated using pyrosequencing. Using weighted gene correlation network analysis, we identified comethylated modules of genes that were associated with key variables such as APOE genotype and diagnosis. In summary, this study represents the first large-scale epigenome-wide association study of Alzheimer's disease and mild cognitive impairment using blood. We highlight the differences in various loci and pathways in early disease, suggesting that these patterns relate to cognitive decline at an early stage.

AB - A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNeuroMed study, which included 89 nondemented controls, 86 patients with Alzheimer's disease, and 109 individuals with mild cognitive impairment, including 38 individuals who progressed to Alzheimer's disease within 1 year. We identified significant differentially methylated regions, including 12 adjacent hypermethylated probes in the HOXB6 gene in Alzheimer's disease, which we validated using pyrosequencing. Using weighted gene correlation network analysis, we identified comethylated modules of genes that were associated with key variables such as APOE genotype and diagnosis. In summary, this study represents the first large-scale epigenome-wide association study of Alzheimer's disease and mild cognitive impairment using blood. We highlight the differences in various loci and pathways in early disease, suggesting that these patterns relate to cognitive decline at an early stage.

KW - Alzheimer's disease (AD)

KW - Biomarker

KW - Blood

KW - DNA methylation

KW - HOXB6

KW - Mild cognitive impairment (MCI)

UR - http://www.scopus.com/inward/record.url?scp=85088797676&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2020.06.023

DO - 10.1016/j.neurobiolaging.2020.06.023

M3 - Article

AN - SCOPUS:85088797676

VL - 95

SP - 26

EP - 45

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -

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