An event related functional magnetic resonance imaging study of facial emotion processing in asperger syndrome

Q Deeley; E M Daly; S Surguladze; L Page; F Toal; D Robertson; S Curran; Vincent Giampietro; M Seal; M J Brammer; Christopher Andrew; K Murphy; M L Phillips; D G M Murphy

doi:10.1016/j.biopsych.2006.09.037

An event related functional magnetic resonance imaging study of facial emotion processing in asperger syndrome

Q Deeley, E M Daly, S Surguladze, L Page, F Toal, D Robertson, S Curran, Vincent Giampietro, M Seal, M J Brammer, Christopher Andrew, K Murphy, M L Phillips, D G M Murphy

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: People with Asperger syndrome (AS) have life-long deficits in social behavior. The biological basis of this is unknown, but most likely includes impaired processing of facial emotion. Human social communication involves processing different facial emotions, and at different intensities. However nobody has examined brain function in people with AS when implicitly (unconsciously) processing four primary emotions at varying emotional intensities. Methods: We used event-related functional magnetic resonance imaging (MRI) to examine neural responses when people with AS and controls implicitly processed neutral expressions, and mild (25%) and intense (100%) expressions of fear, disgust, happiness, and sadness. We included 18 right-handed adults; 9 with AS and 9 healthy controls who did not differ significantly in IQ. Results: Both groups significantly activated 'face perception' areas when viewing neutral faces, including fusiform and extrastriate cortices. Further, both groups had significantly increased activation of fusiform and other extrastriate regions to increasing intensities of fear and happiness. However, people with AS generally showed fusiform and extrastriate hyporesponsiveness compared to controls across emotion types and intensities. Conclusions: Fusiform and extrastriate cortices are activated by facial expressions of four primary emotions in people with AS, but generally to a lesser degree than controls. This may partly explain the social impairments of people with AS

Original language	English
Pages (from-to)	207 - 217
Number of pages	11
Journal	Biological psychiatry
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2006.09.037
Publication status	Published - 1 Aug 2007

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Deeley, Q., Daly, E. M., Surguladze, S., Page, L., Toal, F., Robertson, D., Curran, S., Giampietro, V., Seal, M., Brammer, M. J., Andrew, C., Murphy, K., Phillips, M. L., & Murphy, D. G. M. (2007). An event related functional magnetic resonance imaging study of facial emotion processing in asperger syndrome. Biological psychiatry, 62(3), 207 - 217. https://doi.org/10.1016/j.biopsych.2006.09.037

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title = "An event related functional magnetic resonance imaging study of facial emotion processing in asperger syndrome",

abstract = "Background: People with Asperger syndrome (AS) have life-long deficits in social behavior. The biological basis of this is unknown, but most likely includes impaired processing of facial emotion. Human social communication involves processing different facial emotions, and at different intensities. However nobody has examined brain function in people with AS when implicitly (unconsciously) processing four primary emotions at varying emotional intensities. Methods: We used event-related functional magnetic resonance imaging (MRI) to examine neural responses when people with AS and controls implicitly processed neutral expressions, and mild (25%) and intense (100%) expressions of fear, disgust, happiness, and sadness. We included 18 right-handed adults; 9 with AS and 9 healthy controls who did not differ significantly in IQ. Results: Both groups significantly activated 'face perception' areas when viewing neutral faces, including fusiform and extrastriate cortices. Further, both groups had significantly increased activation of fusiform and other extrastriate regions to increasing intensities of fear and happiness. However, people with AS generally showed fusiform and extrastriate hyporesponsiveness compared to controls across emotion types and intensities. Conclusions: Fusiform and extrastriate cortices are activated by facial expressions of four primary emotions in people with AS, but generally to a lesser degree than controls. This may partly explain the social impairments of people with AS",

author = "Q Deeley and Daly, {E M} and S Surguladze and L Page and F Toal and D Robertson and S Curran and Vincent Giampietro and M Seal and Brammer, {M J} and Christopher Andrew and K Murphy and Phillips, {M L} and Murphy, {D G M}",

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Deeley, Q , Daly, EM , Surguladze, S , Page, L, Toal, F, Robertson, D , Curran, S , Giampietro, V , Seal, M , Brammer, MJ, Andrew, C, Murphy, K , Phillips, ML & Murphy, DGM 2007, 'An event related functional magnetic resonance imaging study of facial emotion processing in asperger syndrome', Biological psychiatry, vol. 62, no. 3, pp. 207 - 217. https://doi.org/10.1016/j.biopsych.2006.09.037

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T1 - An event related functional magnetic resonance imaging study of facial emotion processing in asperger syndrome

AU - Deeley, Q

AU - Daly, E M

AU - Surguladze, S

AU - Page, L

AU - Toal, F

AU - Robertson, D

AU - Curran, S

AU - Giampietro, Vincent

AU - Seal, M

AU - Brammer, M J

AU - Andrew, Christopher

AU - Murphy, K

AU - Phillips, M L

AU - Murphy, D G M

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Background: People with Asperger syndrome (AS) have life-long deficits in social behavior. The biological basis of this is unknown, but most likely includes impaired processing of facial emotion. Human social communication involves processing different facial emotions, and at different intensities. However nobody has examined brain function in people with AS when implicitly (unconsciously) processing four primary emotions at varying emotional intensities. Methods: We used event-related functional magnetic resonance imaging (MRI) to examine neural responses when people with AS and controls implicitly processed neutral expressions, and mild (25%) and intense (100%) expressions of fear, disgust, happiness, and sadness. We included 18 right-handed adults; 9 with AS and 9 healthy controls who did not differ significantly in IQ. Results: Both groups significantly activated 'face perception' areas when viewing neutral faces, including fusiform and extrastriate cortices. Further, both groups had significantly increased activation of fusiform and other extrastriate regions to increasing intensities of fear and happiness. However, people with AS generally showed fusiform and extrastriate hyporesponsiveness compared to controls across emotion types and intensities. Conclusions: Fusiform and extrastriate cortices are activated by facial expressions of four primary emotions in people with AS, but generally to a lesser degree than controls. This may partly explain the social impairments of people with AS

AB - Background: People with Asperger syndrome (AS) have life-long deficits in social behavior. The biological basis of this is unknown, but most likely includes impaired processing of facial emotion. Human social communication involves processing different facial emotions, and at different intensities. However nobody has examined brain function in people with AS when implicitly (unconsciously) processing four primary emotions at varying emotional intensities. Methods: We used event-related functional magnetic resonance imaging (MRI) to examine neural responses when people with AS and controls implicitly processed neutral expressions, and mild (25%) and intense (100%) expressions of fear, disgust, happiness, and sadness. We included 18 right-handed adults; 9 with AS and 9 healthy controls who did not differ significantly in IQ. Results: Both groups significantly activated 'face perception' areas when viewing neutral faces, including fusiform and extrastriate cortices. Further, both groups had significantly increased activation of fusiform and other extrastriate regions to increasing intensities of fear and happiness. However, people with AS generally showed fusiform and extrastriate hyporesponsiveness compared to controls across emotion types and intensities. Conclusions: Fusiform and extrastriate cortices are activated by facial expressions of four primary emotions in people with AS, but generally to a lesser degree than controls. This may partly explain the social impairments of people with AS

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DO - 10.1016/j.biopsych.2006.09.037

M3 - Article

SN - 1873-2402

VL - 62

SP - 207

EP - 217

JO - Biological psychiatry

JF - Biological psychiatry

IS - 3

ER -

An event related functional magnetic resonance imaging study of facial emotion processing in asperger syndrome

Abstract

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