An Exploratory Assessment of Focused Septal Growth in Hypertrophic Cardiomyopathy

Sandra P. Hager*, Will Zhang, Renee M. Miller, Jack Lee, David A. Nordsletten

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Abstract

Growth and Remodelling (G&R) processes are typical responses to changes in the heart’s loading conditions. The most frequent types of growth in the left ventricle (LV) are thought to involve growth parallel to (eccentric) or perpendicular to (concentric) the fiber direction. However, hypertrophic cardiomyopathy (HCM), a genetic mutation of the sarcomeric proteins, exhibits heterogeneous patterns of growth and fiber disarray despite the absence of clear changes in loading conditions. Previous studies have predicted cardiac growth due to increased overload in the heart [7, 12, 23] as well as modelled inverse G&R post-treatment [1, 14]. Since observed growth patterns in HCM are more complex than standard models of hypertrophy in the heart, fewer studies focus on the geometric changes in this pathological case. By adapting established kinematic growth tensors for the standard types of hypertrophy in an isotropic and orthotropic material model, the paper aims to identify different factors which contribute to the heterogeneous growth patterns observed in HCM. Consequently, it was possible to distinguish that fiber disarray alone does not appear to induce the typical phenotypes of HCM. Instead, it appears that an underlying trigger for growth in HCM might be a consequence of factors stimulating isotropic growth (e.g., inflammation). Additionally, morphological changes in the septal region resulted in higher amounts of incompatibility, evidenced by increased residual stresses in the grown region.

Original languageEnglish
Title of host publicationFunctional Imaging and Modeling of the Heart - 11th International Conference, FIMH 2021, Proceedings
EditorsDaniel B. Ennis, Luigi E. Perotti, Vicky Y. Wang
PublisherSpringer Science and Business Media Deutschland GmbH
Pages328-339
Number of pages12
ISBN (Print)9783030787097
DOIs
Publication statusPublished - 2021
Event11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021 - Virtual, Online
Duration: 21 Jun 202125 Jun 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12738 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021
CityVirtual, Online
Period21/06/202125/06/2021

Keywords

  • Computational modelling
  • Growth and Remodelling
  • Hypertrophic cardiomyopathy

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