An innovative design of compaction cell for in situ FT-IR imaging of tablet dissolution

J van der Weerd; KLA Chan; SG Kazarian

doi:10.1016/j.vibspec.2003.11.004

An innovative design of compaction cell for in situ FT-IR imaging of tablet dissolution

J van der Weerd, KLA Chan, SG Kazarian^*

^*Corresponding author for this work

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

This study describes the design and implementation of a new cell, which allows the study of drug release from tablets by macro-Fr-IR ATR imaging with a diamond ATR accessory. The tablet formulation can be compacted directly on the ATR crystal. The distribution of various components in the tablet can be determined by FT-IR imaging. Subsequently, water flow around the tablet can be commenced and the changes in this distribution monitored. Advantages of this system are a high chemical specificity, which allows the analyses of many different materials, and a relatively high spatial resolution. The described cell was applied to study a model tablet consisting of hydroxypropyl methylcellulose (HPMC) and caffeine.

Original language	English
Pages (from-to)	9-13
Number of pages	5
Journal	VIBRATIONAL SPECTROSCOPY
Volume	35
Issue number	1-2
DOIs	https://doi.org/10.1016/j.vibspec.2003.11.004
Publication status	Published - 17 Jun 2004
Event	2nd International Conference on Advanced Vibrational Spectroscopy - Nottingham, United Kingdom Duration: 24 Aug 2003 → 29 Aug 2003

Keywords

FT IR imaging
hydroxypropyl methylcellulose
drug release
ATR-IR
DRUG-RELEASE
SOLUBLE DRUG
MATRICES
POLYMERS

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10.1016/j.vibspec.2003.11.004

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title = "An innovative design of compaction cell for in situ FT-IR imaging of tablet dissolution",

abstract = "This study describes the design and implementation of a new cell, which allows the study of drug release from tablets by macro-Fr-IR ATR imaging with a diamond ATR accessory. The tablet formulation can be compacted directly on the ATR crystal. The distribution of various components in the tablet can be determined by FT-IR imaging. Subsequently, water flow around the tablet can be commenced and the changes in this distribution monitored. Advantages of this system are a high chemical specificity, which allows the analyses of many different materials, and a relatively high spatial resolution. The described cell was applied to study a model tablet consisting of hydroxypropyl methylcellulose (HPMC) and caffeine.",

keywords = "FT IR imaging, hydroxypropyl methylcellulose, drug release, ATR-IR, DRUG-RELEASE, SOLUBLE DRUG, MATRICES, POLYMERS",

author = "{van der Weerd}, J and KLA Chan and SG Kazarian",

year = "2004",

month = jun,

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doi = "10.1016/j.vibspec.2003.11.004",

language = "English",

volume = "35",

pages = "9--13",

journal = "VIBRATIONAL SPECTROSCOPY",

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note = "2nd International Conference on Advanced Vibrational Spectroscopy ; Conference date: 24-08-2003 Through 29-08-2003",

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T1 - An innovative design of compaction cell for in situ FT-IR imaging of tablet dissolution

AU - van der Weerd, J

AU - Chan, KLA

AU - Kazarian, SG

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N2 - This study describes the design and implementation of a new cell, which allows the study of drug release from tablets by macro-Fr-IR ATR imaging with a diamond ATR accessory. The tablet formulation can be compacted directly on the ATR crystal. The distribution of various components in the tablet can be determined by FT-IR imaging. Subsequently, water flow around the tablet can be commenced and the changes in this distribution monitored. Advantages of this system are a high chemical specificity, which allows the analyses of many different materials, and a relatively high spatial resolution. The described cell was applied to study a model tablet consisting of hydroxypropyl methylcellulose (HPMC) and caffeine.

AB - This study describes the design and implementation of a new cell, which allows the study of drug release from tablets by macro-Fr-IR ATR imaging with a diamond ATR accessory. The tablet formulation can be compacted directly on the ATR crystal. The distribution of various components in the tablet can be determined by FT-IR imaging. Subsequently, water flow around the tablet can be commenced and the changes in this distribution monitored. Advantages of this system are a high chemical specificity, which allows the analyses of many different materials, and a relatively high spatial resolution. The described cell was applied to study a model tablet consisting of hydroxypropyl methylcellulose (HPMC) and caffeine.

KW - FT IR imaging

KW - hydroxypropyl methylcellulose

KW - drug release

KW - ATR-IR

KW - DRUG-RELEASE

KW - SOLUBLE DRUG

KW - MATRICES

KW - POLYMERS

U2 - 10.1016/j.vibspec.2003.11.004

DO - 10.1016/j.vibspec.2003.11.004

M3 - Article

SN - 0924-2031

VL - 35

SP - 9

EP - 13

JO - VIBRATIONAL SPECTROSCOPY

JF - VIBRATIONAL SPECTROSCOPY

IS - 1-2

T2 - 2nd International Conference on Advanced Vibrational Spectroscopy

Y2 - 24 August 2003 through 29 August 2003

ER -

An innovative design of compaction cell for in situ FT-IR imaging of tablet dissolution

Abstract

Keywords

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