An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures

TY - CHAP

T1 - An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures

AU - Xia, Wenfeng

AU - Nikitichev, Daniil I.

AU - Mari, Jean Martial

AU - West, Simeon J.

AU - Ourselin, Sebastien

AU - Beard, Paul C.

AU - Desjardins, Adrien E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Precise and efficient guidance of medical devices is of paramount importance for many minimally invasive procedures. These procedures include fetal interventions, tumor biopsies and treatments, central venous catheterisations and peripheral nerve blocks. Ultrasound imaging is commonly used for guidance, but it often provides insufficient contrast with which to identify soft tissue structures such as vessels, tumors, and nerves. In this study, a hybrid interventional imaging system that combines ultrasound imaging and multispectral photoacoustic imaging for guiding minimally invasive procedures was developed and characterized. The system provides both structural information from ultrasound imaging and molecular information from multispectral photoacoustic imaging. It uses a commercial linear-array ultrasound imaging probe as the ultrasound receiver, with a multimode optical fiber embedded in a needle to deliver pulsed excitation light to tissue. Co-registration of ultrasound and photoacoustic images is achieved with the use of the same ultrasound receiver for both modalities. Using tissue ex vivo, the system successfully discriminated deep-located fat tissue from the surrounding muscle tissue. The measured photoacoustic spectrum of the fat tissue had good agreement with the lipid spectrum in literature.

AB - Precise and efficient guidance of medical devices is of paramount importance for many minimally invasive procedures. These procedures include fetal interventions, tumor biopsies and treatments, central venous catheterisations and peripheral nerve blocks. Ultrasound imaging is commonly used for guidance, but it often provides insufficient contrast with which to identify soft tissue structures such as vessels, tumors, and nerves. In this study, a hybrid interventional imaging system that combines ultrasound imaging and multispectral photoacoustic imaging for guiding minimally invasive procedures was developed and characterized. The system provides both structural information from ultrasound imaging and molecular information from multispectral photoacoustic imaging. It uses a commercial linear-array ultrasound imaging probe as the ultrasound receiver, with a multimode optical fiber embedded in a needle to deliver pulsed excitation light to tissue. Co-registration of ultrasound and photoacoustic images is achieved with the use of the same ultrasound receiver for both modalities. Using tissue ex vivo, the system successfully discriminated deep-located fat tissue from the surrounding muscle tissue. The measured photoacoustic spectrum of the fat tissue had good agreement with the lipid spectrum in literature.

KW - Fiber optic

KW - Minimally invasive procedures

KW - Photoacoustic imaging

KW - Ultrasonic tracking

KW - Ultrasound imaging

UR - http://www.scopus.com/inward/record.url?scp=84939551308&partnerID=8YFLogxK

U2 - 10.1117/12.2183798

DO - 10.1117/12.2183798

M3 - Conference paper

AN - SCOPUS:84939551308

VL - 9539

BT - Opto-Acoustic Methods and Applications in Biophotonics II

PB - SPIE

T2 - Opto-Acoustic Methods and Applications in Biophotonics II

Y2 - 22 June 2015 through 23 June 2015

ER -