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An intracerebral hemorrhage care bundle is associated with lower case-fatality

Research output: Contribution to journalArticle

Adrian R Parry-Jones, Camilla Sammut-Powell, Kyriaki Paroutoglou, Emily Birleson, Joshua Rowland, Stephanie Lee, Luca Cecchini, Mark Massyn, Richard Emsley, Benjamin Bray, Hiren Patel

Original languageEnglish
Pages (from-to)495-503
Number of pages9
JournalAnnals of Neurology
Issue number4
Early online date10 Jul 2019
Publication statusPublished - 1 Oct 2019

Bibliographical note

This article is protected by copyright. All rights reserved.


King's Authors


OBJECTIVE: Anticoagulation reversal, intensive blood pressure lowering, neurosurgery and access to critical care might all be beneficial in acute intracerebral hemorrhage (ICH). We combined and implemented these as the 'ABC' hyperacute care bundle and sought to determine whether the implementation was associated with lower case fatality.

METHODS: The ABC bundle was implemented from 1 June 2015 to 31 May 2016. Key process targets were set and a registry captured consecutive patients. We compared 30-day case fatality before, during and after bundle implementation with multivariable logistic regression and used mediation analysis to determine which care process measures mediated any association. Difference-in-difference analysis compared 30-day case fatality with 32,295 patients with ICH from 214 other hospitals in England and Wales using Sentinel Stroke National Audit Programme data.

RESULTS: 973 ICH patients were admitted in the study period. Compared to before implementation, the adjusted odds of death by 30 days were lower in the implementation period (odds ratio [OR] 0·62; 95% confidence interval [CI] 0·38 to 0·97; p=0·03) and this was sustained after implementation (OR 0·40; 95%CI: 0·24 to 0·61; p<0·0001). Implementation of the bundle was associated with a 10·8 pp (95%CI -17·9 to -3·7; p=0·003) reduction in 30-day case fatality in difference-in-difference analysis. The total effect of the care bundle was mediated by a reduction in do-not-resuscitate orders within 24 h (52·8%) and increased admission to critical care (11·1%).

INTERPRETATION: Implementation of the ABC care bundle was significantly associated with lower 30-day case fatality after ICH. This article is protected by copyright. All rights reserved.

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