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An investigation into how the radiotherapy dose response of normal appearing brain tissue in glioma patients influences ADC measurements.

Research output: Contribution to journalArticle

Original languageEnglish
JournalProceedings of SPIE
Published28 Jun 2018

King's Authors


Functional diffusion map (fDM) analysis has been shown to be potentially useful in categorizing treatment response in glioma patients. Such fDMs are created using subtracted longitudinal ADC images, which are segmented to quantify regions of significant increases and decreases in ADC values. Thresholds demarcating significant change have been defined in the literature by sampling longitudinal changes in contralateral normal appearing brain tissue (NABT) in the patient population that was being studied. A recent publication has shown that the use of contralateral NABT to aid absolute quantification of CBV and CBF values due to radiation induced changes to dynamic susceptibility contrast MRI (DSC) parameters is inappropriate. We have investigated how the radiotherapy (RT) dose response of contralateral NABT influences ADC measurements.

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