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An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris

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An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. / Ormond, M; McParland, H; Donaldson, ANA et al.

In: British Journal of Dermatology, Vol. 179, No. 4, 179, 28.04.2018, p. 872-881.

Research output: Contribution to journalArticlepeer-review

Harvard

Ormond, M, McParland, H, Donaldson, ANA, Andiappan, M, Cook, RJ, Escudier, M, Hullah, E, Higham, J, McMillan, R, Taylor, J, Shirlaw, PJ, Challacombe, SJ & Setterfield, JF 2018, 'An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris', British Journal of Dermatology, vol. 179, no. 4, 179, pp. 872-881. https://doi.org/10.1111/bjd.16265

APA

Ormond, M., McParland, H., Donaldson, ANA., Andiappan, M., Cook, RJ., Escudier, M., Hullah, E., Higham, J., McMillan, R., Taylor, J., Shirlaw, PJ., Challacombe, SJ., & Setterfield, JF. (2018). An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. British Journal of Dermatology, 179(4), 872-881. [179]. https://doi.org/10.1111/bjd.16265

Vancouver

Ormond M, McParland H, Donaldson ANA, Andiappan M, Cook RJ, Escudier M et al. An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. British Journal of Dermatology. 2018 Apr 28;179(4):872-881. 179. https://doi.org/10.1111/bjd.16265

Author

Ormond, M ; McParland, H ; Donaldson, ANA et al. / An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. In: British Journal of Dermatology. 2018 ; Vol. 179, No. 4. pp. 872-881.

Bibtex Download

@article{d32e35e92fe74dd6b9e88f7238cf7fc9,
title = "An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris",
abstract = "Objectives The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in pemphigus vulgaris (PV). A secondary aim was to compare the inter – intra- observer variability and ease of use with the Physician's Global Assessment (PGA) and the oral scoring methods used in Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and the Pemphigus Disease Area Index (PDAI). Methods 15 patients with mild to moderately severe oral PV were scored for disease severity by 10 oral medicine clinicians using the ODSS, PGA and the oral sections of ABSIS and PDAI. Two clinicians re-scored all patients after a minimum two-hour interval. Results Inter-observer reliability was assessed using an intra-class correlation coefficient (ICC). For the ODSS total score the ICC was 0.83, PDAI (oral total activity) 0.79 ABSIS (oral total) 0.71 and PGA was 0.7. Intra-observer agreement between initial scoring and re-scoring of the same subject by two clinicians demonstrated an ICC for each of 0.97 and 0.96 for ODSS total score; 0.99 and 0.82 for the PDAI oral activity; 0.86 and 0.45 for the ABSIS total and 0.99 and 0.64 for the PGA. Convergent validity was good with a correlation coefficient of greater than 0.5 (p<0.0001). The mean time (SD) (seconds) taken to complete each scoring method was: ODSS 76±37; PDAI 117±16; ABSIS 75±19. Conclusion This study has validated the ODSS for the assessment of oral PV. It has shown superior inter- and intra-observer reliability to PDAI, ABSIS and PGA and is quick to perform.",
author = "M Ormond and H McParland and ANA Donaldson and M Andiappan and RJ Cook and M Escudier and E Hullah and J Higham and R McMillan and J Taylor and PJ Shirlaw and SJ Challacombe and JF Setterfield",
year = "2018",
month = apr,
day = "28",
doi = "10.1111/bjd.16265",
language = "English",
volume = "179",
pages = "872--881",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris

AU - Ormond, M

AU - McParland, H

AU - Donaldson, ANA

AU - Andiappan, M

AU - Cook, RJ

AU - Escudier, M

AU - Hullah, E

AU - Higham, J

AU - McMillan, R

AU - Taylor, J

AU - Shirlaw, PJ

AU - Challacombe, SJ

AU - Setterfield, JF

PY - 2018/4/28

Y1 - 2018/4/28

N2 - Objectives The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in pemphigus vulgaris (PV). A secondary aim was to compare the inter – intra- observer variability and ease of use with the Physician's Global Assessment (PGA) and the oral scoring methods used in Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and the Pemphigus Disease Area Index (PDAI). Methods 15 patients with mild to moderately severe oral PV were scored for disease severity by 10 oral medicine clinicians using the ODSS, PGA and the oral sections of ABSIS and PDAI. Two clinicians re-scored all patients after a minimum two-hour interval. Results Inter-observer reliability was assessed using an intra-class correlation coefficient (ICC). For the ODSS total score the ICC was 0.83, PDAI (oral total activity) 0.79 ABSIS (oral total) 0.71 and PGA was 0.7. Intra-observer agreement between initial scoring and re-scoring of the same subject by two clinicians demonstrated an ICC for each of 0.97 and 0.96 for ODSS total score; 0.99 and 0.82 for the PDAI oral activity; 0.86 and 0.45 for the ABSIS total and 0.99 and 0.64 for the PGA. Convergent validity was good with a correlation coefficient of greater than 0.5 (p<0.0001). The mean time (SD) (seconds) taken to complete each scoring method was: ODSS 76±37; PDAI 117±16; ABSIS 75±19. Conclusion This study has validated the ODSS for the assessment of oral PV. It has shown superior inter- and intra-observer reliability to PDAI, ABSIS and PGA and is quick to perform.

AB - Objectives The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in pemphigus vulgaris (PV). A secondary aim was to compare the inter – intra- observer variability and ease of use with the Physician's Global Assessment (PGA) and the oral scoring methods used in Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and the Pemphigus Disease Area Index (PDAI). Methods 15 patients with mild to moderately severe oral PV were scored for disease severity by 10 oral medicine clinicians using the ODSS, PGA and the oral sections of ABSIS and PDAI. Two clinicians re-scored all patients after a minimum two-hour interval. Results Inter-observer reliability was assessed using an intra-class correlation coefficient (ICC). For the ODSS total score the ICC was 0.83, PDAI (oral total activity) 0.79 ABSIS (oral total) 0.71 and PGA was 0.7. Intra-observer agreement between initial scoring and re-scoring of the same subject by two clinicians demonstrated an ICC for each of 0.97 and 0.96 for ODSS total score; 0.99 and 0.82 for the PDAI oral activity; 0.86 and 0.45 for the ABSIS total and 0.99 and 0.64 for the PGA. Convergent validity was good with a correlation coefficient of greater than 0.5 (p<0.0001). The mean time (SD) (seconds) taken to complete each scoring method was: ODSS 76±37; PDAI 117±16; ABSIS 75±19. Conclusion This study has validated the ODSS for the assessment of oral PV. It has shown superior inter- and intra-observer reliability to PDAI, ABSIS and PGA and is quick to perform.

U2 - 10.1111/bjd.16265

DO - 10.1111/bjd.16265

M3 - Article

VL - 179

SP - 872

EP - 881

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 4

M1 - 179

ER -

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