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An update of the impact of deep brain stimulation on non motor symptoms in Parkinson's disease

Research output: Contribution to journalArticlepeer-review

Lisa Klingelhoefer, Michael Samuel, Keyoumars Ashkan, Kallol Ray Chaudhuri

Original languageEnglish
Pages (from-to)289-300
Number of pages12
JournalJournal of parkinsons disease
Issue number2

King's Authors


Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for patients with Parkinson's disease (PD), especially those with advanced motor complications. The effect of STN DBS on non motor symptoms (NMS) of PD is less well studied. In this article, we review the pertinent literature on the impact of STN DBS on NMS when they co-exist with disabling motor symptoms in PD patients. We also present evidence that the number and the severity of most NMS decrease after STN DBS which can have a major impact on patients' quality of life.

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