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An update on adrenocortical cell lines of human origin

Research output: Contribution to journalReview articlepeer-review

Sandra Sigala, Elisa Rossini, Andrea Abate, Mariangela Tamburello, Stefan R. Bornstein, Constanze Hantel

Original languageEnglish
Pages (from-to)432-437
Number of pages6
JournalENDOCRINE
Volume77
Issue number3
DOIs
Accepted/In press2022
PublishedSep 2022

Bibliographical note

Publisher Copyright: © 2022, The Author(s).

King's Authors

Abstract

Adrenocortical carcinoma (ACC) is a rare, heterogenous and highly malignant disease. Management of ACC is dependent on disease stage with complete surgical resection as the only potentially curative option. However, advanced, un-resectable, metastatic stages and also recurrences often require systemic treatments, which are unfortunately nowadays still unsatisfactory. The scarcity of preclinical models reflecting patient heterogeneities and furthermore drug-resistant phenotypes, has hampered the progress and development of new therapies in recent years. In this review, we provide an overview on the classical models and substantial progress which has been made over the last years in context of this aggressive disease.

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