An Update: Pathophysiology of Migraine

TY - JOUR

T1 - An Update

T2 - Pathophysiology of Migraine

AU - Goadsby, Peter J

AU - Holland, Philip R

PY - 2019/11

Y1 - 2019/11

N2 - Migraine is the most common disabling primary headache globally. Attacks typically present with unilateral throbbing headache and associated symptoms including, nausea, multisensory hypersensitivity, and marked fatigue. In this article, the authors address the underlying neuroanatomical basis for migraine-related headache, associated symptomatology, and discuss key clinical and preclinical findings that indicate that migraine likely results from dysfunctional homeostatic mechanisms. Whereby, abnormal central nervous system responses to extrinsic and intrinsic cues may lead to increased attack susceptibility.

AB - Migraine is the most common disabling primary headache globally. Attacks typically present with unilateral throbbing headache and associated symptoms including, nausea, multisensory hypersensitivity, and marked fatigue. In this article, the authors address the underlying neuroanatomical basis for migraine-related headache, associated symptomatology, and discuss key clinical and preclinical findings that indicate that migraine likely results from dysfunctional homeostatic mechanisms. Whereby, abnormal central nervous system responses to extrinsic and intrinsic cues may lead to increased attack susceptibility.

KW - Aura

KW - Cortical spreading depression

KW - Headache

KW - Homeostatic networks

KW - Migraine

KW - Pain

KW - Trigeminal

KW - Trigeminovascular system

UR - http://www.scopus.com/inward/record.url?scp=85072622711&partnerID=8YFLogxK

U2 - 10.1016/j.ncl.2019.07.008

DO - 10.1016/j.ncl.2019.07.008

M3 - Review article

C2 - 31563225

AN - SCOPUS:85072622711

SN - 0733-8619

VL - 37

SP - 651

EP - 671

JO - Neurologic Clinics

JF - Neurologic Clinics

IS - 4

ER -