An updated view on stem cell differentiation into smooth muscle cells

Li Zhang; Yijiang Zhou; Jianhua Zhu; Qingbo Xu

doi:10.1016/j.vph.2012.02.014

An updated view on stem cell differentiation into smooth muscle cells

Li Zhang, Yijiang Zhou, Jianhua Zhu, Qingbo Xu

Cardiovascular Sciences

Research output: Contribution to journal › Literature review › peer-review

12 Citations (Scopus)

Abstract

Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs play a profound role in blood vessel physiology and participate in a number of cardiovascular diseases such as atherosclerosis, hypertension and restenosis. In addition, SMCs could be a crucial cell component for vascular tissue engineering. In this review, we aim to update the recent progress on the mechanisms of SMC differentiation from stem cells, which involve reactive oxygen species, epigenetic modifiers, transcription factors and microRNAs coordinately regulated during stem cell differentiation. We will also discuss the potential application of stem cell therapy for patients with cardiovascular diseases. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	280-287
Number of pages	8
Journal	VASCULAR PHARMACOLOGY
Volume	56
Issue number	5-6
DOIs	https://doi.org/10.1016/j.vph.2012.02.014
Publication status	Published - 2012

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10.1016/j.vph.2012.02.014

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title = "An updated view on stem cell differentiation into smooth muscle cells",

abstract = "Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs play a profound role in blood vessel physiology and participate in a number of cardiovascular diseases such as atherosclerosis, hypertension and restenosis. In addition, SMCs could be a crucial cell component for vascular tissue engineering. In this review, we aim to update the recent progress on the mechanisms of SMC differentiation from stem cells, which involve reactive oxygen species, epigenetic modifiers, transcription factors and microRNAs coordinately regulated during stem cell differentiation. We will also discuss the potential application of stem cell therapy for patients with cardiovascular diseases. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.",

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AU - Zhang, Li

AU - Zhou, Yijiang

AU - Zhu, Jianhua

AU - Xu, Qingbo

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Y1 - 2012

N2 - Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs play a profound role in blood vessel physiology and participate in a number of cardiovascular diseases such as atherosclerosis, hypertension and restenosis. In addition, SMCs could be a crucial cell component for vascular tissue engineering. In this review, we aim to update the recent progress on the mechanisms of SMC differentiation from stem cells, which involve reactive oxygen species, epigenetic modifiers, transcription factors and microRNAs coordinately regulated during stem cell differentiation. We will also discuss the potential application of stem cell therapy for patients with cardiovascular diseases. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.

AB - Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs play a profound role in blood vessel physiology and participate in a number of cardiovascular diseases such as atherosclerosis, hypertension and restenosis. In addition, SMCs could be a crucial cell component for vascular tissue engineering. In this review, we aim to update the recent progress on the mechanisms of SMC differentiation from stem cells, which involve reactive oxygen species, epigenetic modifiers, transcription factors and microRNAs coordinately regulated during stem cell differentiation. We will also discuss the potential application of stem cell therapy for patients with cardiovascular diseases. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.

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DO - 10.1016/j.vph.2012.02.014

M3 - Literature review

SN - 1537-1891

VL - 56

SP - 280

EP - 287

JO - VASCULAR PHARMACOLOGY

JF - VASCULAR PHARMACOLOGY

IS - 5-6

ER -

An updated view on stem cell differentiation into smooth muscle cells

Abstract

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