Analysis of the interactions of migrating macrophages

José Alonso Solís-Lemus*, Brian Stramer, Greg Slabaugh, Constantino Carlos Reyes-Aldasoro

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

2 Citations (Scopus)

Abstract

Understanding the migrating patterns of cells in the immune system is of great importance; especially the changes of direction and its cause. For macrophages and other immune cells, excessive migration could be related to autoimmune diseases and cancer. In this work, an algorithm to analyse the change in direction of cells before and after they interact with another cell is proposed. The main objective is to provide insights into the notion that interactions between cell structures appear to anticipate migration. Such interactions are determined when the cells overlap and form clumps of two or more cells. The algorithm integrates a segmentation technique capable of detecting overlapping cells and a tracking framework into a tool for the analysis of the trajectories of cells before and after they overlap. The preliminary results show promise into the analysis and the hypothesis proposed, and it lays the ground work for further developments.

Original languageEnglish
Title of host publicationMedical Image Understanding and Analysis - 22nd Conference, Proceedings
EditorsMark Nixon, Sasan Mahmoodi, Reyer Zwiggelaar
PublisherSpringer Verlag
Pages262-273
Number of pages12
ISBN (Print)9783319959207
DOIs
Publication statusPublished - 1 Jan 2018
Event22nd Conference on Medical Image Understanding and Analysis, MIUA 2018 - Southampton, United Kingdom
Duration: 9 Jul 201811 Jul 2018

Publication series

NameCommunications in Computer and Information Science
Volume894
ISSN (Print)1865-0929

Conference

Conference22nd Conference on Medical Image Understanding and Analysis, MIUA 2018
Country/TerritoryUnited Kingdom
CitySouthampton
Period9/07/201811/07/2018

Keywords

  • Cell tracking
  • Macrophages
  • Segmentation
  • Track analysis

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