Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study

Perry T C van Doormaal, Nicola Ticozzi, Cinzia Gellera, Antonia Ratti, Franco Taroni, Adriano Chiò, Andrea Calvo, Gabriele Mora, Gabriella Restagno, Bryan J Traynor, Anna Birve, Robin Lemmens, Michael A van Es, Christiaan G J Saris, Hylke M Blauw, Paul W J van Vught, Ewout J N Groen, Lucia Corrado, Letizia Mazzini, Roberto Del BoStefania Corti, Stefan Waibel, Thomas Meyer, Albert C Ludolph, An Goris, Philip van Damme, Wim Robberecht, Aleksey Shatunov, Isabella Fogh, Peter M Andersen, Sandra D'Alfonso, Orla Hardiman, Simon Cronin, Dan Rujescu, Ammar Al-Chalabi, John E Landers, Vincenzo Silani, Leonard H van den Berg, Jan H Veldink

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.
Original languageEnglish
Pages (from-to)2420.e13-2420.e14
Number of pages2
JournalNeurobiology of Aging
Issue number10
Publication statusPublished - Oct 2014


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