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Analytical characterization of three cathinone derivatives, 4-MPD, 4 F-PHP and bk-EPDP, purchased as bulk powder from online vendors

Research output: Contribution to journalArticle

Orapan Apirakkan, Anca Frinculescu, Trevor Shine, Mark C. Parkin, Agostino Cilibrizzi, Nunzianda Frascione, Vincenzo Abbate

Original languageEnglish
JournalDrug Testing And Analysis
Early online date18 Jul 2017
Accepted/In press18 May 2017
E-pub ahead of print18 Jul 2017


  • Analytical characterization of three_APIRAKKAN_Publishedonline18July2017_GREEN AAM

    Analytical_characterization_of_three_APIRAKKAN_Publishedonline18July2017_GREEN_AAM.pdf, 145 KB, application/pdf

    Uploaded date:01 Aug 2017

    Version:Accepted author manuscript

    This is the peer reviewed version of the following article: Apirakkan, O. et al., in Drug Testing And Analysis (Wiley: 2017), which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

King's Authors


Novel emerging drugs of abuse, also referred as new psychoactive substances (NPS), constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One of such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them. By using complementary analytical techniques (i.e. 1D and 2D NMR, FT-IR, GC-MS, HRMS and HPLC-UV), this study investigates the detection, identification and full characterization of 1-(4-methylphenyl)-2-(methylamino)-pentanone (4-methyl-pentedrone, 4-MPD), 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)-hexanone (4 F-PHP) and 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-1-pentanone (bk-EPDP), three emerging cathinone derivatives.

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