Analytical strategies to study the gut microbiome in toxicology

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Bacteria in the gut have the ability to affect the toxicity of chemicals. The development of laboratory-based models to study the toxicity of chemicals on the gut microbiome in the context of regulatory health risk assessments is still in its infancy. We provide an overview of the different DNA sequencing strategies to study the gut microbiome, illustrated by results of studies investigating the effects of the herbicide glyphosate. This provides a list of actionable points that may help the scientific community improve the quality of gut microbiome animal toxicity studies. More studies are needed to improve the standardization of generating, storing, and analyzing microbiome data, but also to unravel knowledge gaps such as the need for the definition of a healthy microbiome, as well as the need for research on host-microbiome interactions and its pathological aspects.

Original languageEnglish
Title of host publicationToxicological Risk Assessment and Multi-System Health Impacts from Exposure
Number of pages9
ISBN (Electronic)9780323852159
Publication statusPublished - 1 Jan 2021


  • DNA sequencing
  • Glyphosate
  • Gut microbiome
  • Metabolomics
  • Metagenomics


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