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Anatomical evidence of an indirect pathway for word repetition

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Anatomical evidence of an indirect pathway for word repetition. / Forkel, Stephanie J.; Rogalski, Emily; Drossinos Sancho, Niki; D'Anna, Lucio; Luque Laguna, Pedro; Sridhar, Jaiashre; Dell'Acqua, Flavio; Weintraub, Sandra; Thompson, Cynthia; Mesulam, M.-marsel; Catani, Marco.

In: Neurology, Vol. 94, No. 6, 11.02.2020, p. e594-e606.

Research output: Contribution to journalArticle

Harvard

Forkel, SJ, Rogalski, E, Drossinos Sancho, N, D'Anna, L, Luque Laguna, P, Sridhar, J, Dell'Acqua, F, Weintraub, S, Thompson, C, Mesulam, M & Catani, M 2020, 'Anatomical evidence of an indirect pathway for word repetition', Neurology, vol. 94, no. 6, pp. e594-e606. https://doi.org/10.1212/WNL.0000000000008746

APA

Forkel, S. J., Rogalski, E., Drossinos Sancho, N., D'Anna, L., Luque Laguna, P., Sridhar, J., Dell'Acqua, F., Weintraub, S., Thompson, C., Mesulam, M. ., & Catani, M. (2020). Anatomical evidence of an indirect pathway for word repetition. Neurology, 94(6), e594-e606. https://doi.org/10.1212/WNL.0000000000008746

Vancouver

Forkel SJ, Rogalski E, Drossinos Sancho N, D'Anna L, Luque Laguna P, Sridhar J et al. Anatomical evidence of an indirect pathway for word repetition. Neurology. 2020 Feb 11;94(6):e594-e606. https://doi.org/10.1212/WNL.0000000000008746

Author

Forkel, Stephanie J. ; Rogalski, Emily ; Drossinos Sancho, Niki ; D'Anna, Lucio ; Luque Laguna, Pedro ; Sridhar, Jaiashre ; Dell'Acqua, Flavio ; Weintraub, Sandra ; Thompson, Cynthia ; Mesulam, M.-marsel ; Catani, Marco. / Anatomical evidence of an indirect pathway for word repetition. In: Neurology. 2020 ; Vol. 94, No. 6. pp. e594-e606.

Bibtex Download

@article{f97b61996200485ba08d3c4527d61f6c,
title = "Anatomical evidence of an indirect pathway for word repetition",
abstract = "OBJECTIVE: To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). METHODS: The traditional anatomical model of language identifies a network for word repetition that includes Wernicke and Broca regions directly connected via the arcuate fasciculus. Recent tractography findings of an indirect pathway between Wernicke and Broca regions suggest a critical role of the inferior parietal lobe for repetition. To test whether repetition deficits are associated with damage to the direct or indirect pathway between both regions, tractography analysis was performed in 30 patients with PPA (64.27 ± 8.51 years) and 22 healthy controls. Cortical volume measurements were also extracted from 8 perisylvian language areas connected by the direct and indirect pathways. RESULTS: Compared to healthy controls, patients with PPA presented with reduced performance in repetition tasks and increased damage to most of the perisylvian cortical regions and their connections through the indirect pathway. Repetition deficits were prominent in patients with cortical atrophy of the temporo-parietal region with volumetric reductions of the indirect pathway. CONCLUSIONS: The results suggest that in PPA, deficits in repetition are due to damage to the temporo-parietal cortex and its connections to Wernicke and Broca regions. We therefore propose a revised language model that also includes an indirect pathway for repetition, which has important clinical implications for the functional mapping and treatment of neurologic patients.",
author = "Forkel, {Stephanie J.} and Emily Rogalski and {Drossinos Sancho}, Niki and Lucio D'Anna and {Luque Laguna}, Pedro and Jaiashre Sridhar and Flavio Dell'Acqua and Sandra Weintraub and Cynthia Thompson and M.-marsel Mesulam and Marco Catani",
year = "2020",
month = feb,
day = "11",
doi = "10.1212/WNL.0000000000008746",
language = "English",
volume = "94",
pages = "e594--e606",
journal = "Neurology",
issn = "0028-3878",
number = "6",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Anatomical evidence of an indirect pathway for word repetition

AU - Forkel, Stephanie J.

AU - Rogalski, Emily

AU - Drossinos Sancho, Niki

AU - D'Anna, Lucio

AU - Luque Laguna, Pedro

AU - Sridhar, Jaiashre

AU - Dell'Acqua, Flavio

AU - Weintraub, Sandra

AU - Thompson, Cynthia

AU - Mesulam, M.-marsel

AU - Catani, Marco

PY - 2020/2/11

Y1 - 2020/2/11

N2 - OBJECTIVE: To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). METHODS: The traditional anatomical model of language identifies a network for word repetition that includes Wernicke and Broca regions directly connected via the arcuate fasciculus. Recent tractography findings of an indirect pathway between Wernicke and Broca regions suggest a critical role of the inferior parietal lobe for repetition. To test whether repetition deficits are associated with damage to the direct or indirect pathway between both regions, tractography analysis was performed in 30 patients with PPA (64.27 ± 8.51 years) and 22 healthy controls. Cortical volume measurements were also extracted from 8 perisylvian language areas connected by the direct and indirect pathways. RESULTS: Compared to healthy controls, patients with PPA presented with reduced performance in repetition tasks and increased damage to most of the perisylvian cortical regions and their connections through the indirect pathway. Repetition deficits were prominent in patients with cortical atrophy of the temporo-parietal region with volumetric reductions of the indirect pathway. CONCLUSIONS: The results suggest that in PPA, deficits in repetition are due to damage to the temporo-parietal cortex and its connections to Wernicke and Broca regions. We therefore propose a revised language model that also includes an indirect pathway for repetition, which has important clinical implications for the functional mapping and treatment of neurologic patients.

AB - OBJECTIVE: To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). METHODS: The traditional anatomical model of language identifies a network for word repetition that includes Wernicke and Broca regions directly connected via the arcuate fasciculus. Recent tractography findings of an indirect pathway between Wernicke and Broca regions suggest a critical role of the inferior parietal lobe for repetition. To test whether repetition deficits are associated with damage to the direct or indirect pathway between both regions, tractography analysis was performed in 30 patients with PPA (64.27 ± 8.51 years) and 22 healthy controls. Cortical volume measurements were also extracted from 8 perisylvian language areas connected by the direct and indirect pathways. RESULTS: Compared to healthy controls, patients with PPA presented with reduced performance in repetition tasks and increased damage to most of the perisylvian cortical regions and their connections through the indirect pathway. Repetition deficits were prominent in patients with cortical atrophy of the temporo-parietal region with volumetric reductions of the indirect pathway. CONCLUSIONS: The results suggest that in PPA, deficits in repetition are due to damage to the temporo-parietal cortex and its connections to Wernicke and Broca regions. We therefore propose a revised language model that also includes an indirect pathway for repetition, which has important clinical implications for the functional mapping and treatment of neurologic patients.

UR - http://www.scopus.com/inward/record.url?scp=85079251117&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000008746

DO - 10.1212/WNL.0000000000008746

M3 - Article

VL - 94

SP - e594-e606

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -

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