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Aneuploidy and loss of heterozygosity as risk markers for malignant transformation in oral mucosa

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1993-2007
Number of pages15
JournalOral Diseases
Issue number8
Early online date26 Feb 2021
Accepted/In press2021
E-pub ahead of print26 Feb 2021
PublishedNov 2021

Bibliographical note

Funding Information: I thank the Royal College of Physicians and Surgeons (RCPSG) for providing logistic support for holding this expert symposium and Henry Schein Cares for an educational grant for travel expenses of some invited experts who attended the workshop. Publisher Copyright: © 2021 The Authors. Oral Diseases published by Wiley Periodicals LLC.

King's Authors


The ability to predict malignant transformation in oral potentially malignant disorders would inform targeted treatment, provide prognostic information and allow secondary prevention. DNA ploidy and loss of heterozygosity assays are already in clinical use, and loss of heterozygosity has been used in prospective clinical trials. This review appraises published evidence of predictive ability and explores interpretation of heterogeneous studies, with different diagnostic methods, criteria and intention. Both methods have a sound biological foundation and have predictive value independent of dysplasia grading and clinical parameters. The application of these two techniques cannot be directly compared because of differences in expression of results and application to populations of different risk. Predicting malignant transformation accurately on an individual patient basis is not yet possible with either technique. However, they are valuable applications to stratify patients for inclusion in trials, identify the lowest risk patients and exclude risk when biopsy results are indeterminate for dysplasia.

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