Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity

Taylor F Smith; Arthur D Anastopoulos; Melanie E Garrett; Alejandro Arias-Vasquez; Barbara Franke; Robert D Oades; Edmund Sonuga-Barke; Philip Asherson; Michael Gill; Jan K Buitelaar; Joseph A Sergeant; Scott H Kollins; Stephen V Faraone; Allison Ashley-Koch; the IMAGE Consortium

doi:10.1002/ajmg.b.32275

Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity

Taylor F Smith, Arthur D Anastopoulos, Melanie E Garrett, Alejandro Arias-Vasquez, Barbara Franke, Robert D Oades, Edmund Sonuga-Barke, Philip Asherson, Michael Gill, Jan K Buitelaar, Joseph A Sergeant, Scott H Kollins, Stephen V Faraone, Allison Ashley-Koch, the IMAGE Consortium

Department of Psychology and Child Development, California Polytechnic State University, San Luis Obispo, California; Department of Psychology, University of North Carolina at Greensboro, Greensboro, North Carolina.

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Low birth weight is associated with increased risk for Attention-Deficit/Hyperactivity Disorder (ADHD); however, the etiological underpinnings of this relationship remain unclear. This study investigated if genetic variants in angiogenic, dopaminergic, neurotrophic, kynurenine, and cytokine-related biological pathways moderate the relationship between birth weight and ADHD symptom severity. A total of 398 youth from two multi-site, family-based studies of ADHD were included in the analysis. The sample consisted of 360 ADHD probands, 21 affected siblings, and 17 unaffected siblings. A set of 164 SNPs from 31 candidate genes, representing five biological pathways, were included in our analyses. Birth weight and gestational age data were collected from a state birth registry, medical records, and parent report. Generalized Estimating Equations tested for main effects and interactions between individual SNPs and birth weight centile in predicting ADHD symptom severity. SNPs within neurotrophic (NTRK3) and cytokine genes (CNTFR) were associated with ADHD inattentive symptom severity. There was no main effect of birth weight centile on ADHD symptom severity. SNPs within angiogenic (NRP1 & NRP2), neurotrophic (NTRK1 & NTRK3), cytokine (IL16 & S100B), and kynurenine (CCBL1 & CCBL2) genes moderate the association between birth weight centile and ADHD symptom severity. The SNP main effects and SNP × birth weight centile interactions remained significant after adjusting for multiple testing. Genetic variability in angiogenic, neurotrophic, and inflammatory systems may moderate the association between restricted prenatal growth, a proxy for an adverse prenatal environment, and risk to develop ADHD.

Original language	English
Pages (from-to)	691-704
Number of pages	14
Journal	American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Volume	165
Issue number	8
Early online date	25 Oct 2014
DOIs	https://doi.org/10.1002/ajmg.b.32275
Publication status	Published - Dec 2014

Access to Document

10.1002/ajmg.b.32275

Cite this

Smith, T. F., Anastopoulos, A. D., Garrett, M. E., Arias-Vasquez, A., Franke, B., Oades, R. D., Sonuga-Barke, E., Asherson, P., Gill, M., Buitelaar, J. K., Sergeant, J. A., Kollins, S. H., Faraone, S. V., Ashley-Koch, A., & the IMAGE Consortium (2014). Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 165(8), 691-704. https://doi.org/10.1002/ajmg.b.32275

Smith, Taylor F ; Anastopoulos, Arthur D ; Garrett, Melanie E et al. / Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity. In: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2014 ; Vol. 165, No. 8. pp. 691-704.

@article{719b6cc64b6b4febb48735dfff95c337,

title = "Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity",

abstract = "Low birth weight is associated with increased risk for Attention-Deficit/Hyperactivity Disorder (ADHD); however, the etiological underpinnings of this relationship remain unclear. This study investigated if genetic variants in angiogenic, dopaminergic, neurotrophic, kynurenine, and cytokine-related biological pathways moderate the relationship between birth weight and ADHD symptom severity. A total of 398 youth from two multi-site, family-based studies of ADHD were included in the analysis. The sample consisted of 360 ADHD probands, 21 affected siblings, and 17 unaffected siblings. A set of 164 SNPs from 31 candidate genes, representing five biological pathways, were included in our analyses. Birth weight and gestational age data were collected from a state birth registry, medical records, and parent report. Generalized Estimating Equations tested for main effects and interactions between individual SNPs and birth weight centile in predicting ADHD symptom severity. SNPs within neurotrophic (NTRK3) and cytokine genes (CNTFR) were associated with ADHD inattentive symptom severity. There was no main effect of birth weight centile on ADHD symptom severity. SNPs within angiogenic (NRP1 & NRP2), neurotrophic (NTRK1 & NTRK3), cytokine (IL16 & S100B), and kynurenine (CCBL1 & CCBL2) genes moderate the association between birth weight centile and ADHD symptom severity. The SNP main effects and SNP × birth weight centile interactions remained significant after adjusting for multiple testing. Genetic variability in angiogenic, neurotrophic, and inflammatory systems may moderate the association between restricted prenatal growth, a proxy for an adverse prenatal environment, and risk to develop ADHD.",

author = "Smith, {Taylor F} and Anastopoulos, {Arthur D} and Garrett, {Melanie E} and Alejandro Arias-Vasquez and Barbara Franke and Oades, {Robert D} and Edmund Sonuga-Barke and Philip Asherson and Michael Gill and Buitelaar, {Jan K} and Sergeant, {Joseph A} and Kollins, {Scott H} and Faraone, {Stephen V} and Allison Ashley-Koch and {the IMAGE Consortium} and Robert Plomin",

year = "2014",

month = dec,

doi = "10.1002/ajmg.b.32275",

language = "English",

volume = "165",

pages = "691--704",

journal = "American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics",

issn = "1552-485X",

publisher = "Wiley",

number = "8",

}

Smith, TF, Anastopoulos, AD, Garrett, ME, Arias-Vasquez, A, Franke, B, Oades, RD, Sonuga-Barke, E , Asherson, P, Gill, M, Buitelaar, JK, Sergeant, JA, Kollins, SH, Faraone, SV, Ashley-Koch, A & the IMAGE Consortium 2014, 'Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity', American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, vol. 165, no. 8, pp. 691-704. https://doi.org/10.1002/ajmg.b.32275

Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity. / Smith, Taylor F; Anastopoulos, Arthur D; Garrett, Melanie E et al.
In: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 165, No. 8, 12.2014, p. 691-704.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity

AU - Smith, Taylor F

AU - Anastopoulos, Arthur D

AU - Garrett, Melanie E

AU - Arias-Vasquez, Alejandro

AU - Franke, Barbara

AU - Oades, Robert D

AU - Sonuga-Barke, Edmund

AU - Asherson, Philip

AU - Gill, Michael

AU - Buitelaar, Jan K

AU - Sergeant, Joseph A

AU - Kollins, Scott H

AU - Faraone, Stephen V

AU - Ashley-Koch, Allison

AU - the IMAGE Consortium

AU - Plomin, Robert

PY - 2014/12

Y1 - 2014/12

N2 - Low birth weight is associated with increased risk for Attention-Deficit/Hyperactivity Disorder (ADHD); however, the etiological underpinnings of this relationship remain unclear. This study investigated if genetic variants in angiogenic, dopaminergic, neurotrophic, kynurenine, and cytokine-related biological pathways moderate the relationship between birth weight and ADHD symptom severity. A total of 398 youth from two multi-site, family-based studies of ADHD were included in the analysis. The sample consisted of 360 ADHD probands, 21 affected siblings, and 17 unaffected siblings. A set of 164 SNPs from 31 candidate genes, representing five biological pathways, were included in our analyses. Birth weight and gestational age data were collected from a state birth registry, medical records, and parent report. Generalized Estimating Equations tested for main effects and interactions between individual SNPs and birth weight centile in predicting ADHD symptom severity. SNPs within neurotrophic (NTRK3) and cytokine genes (CNTFR) were associated with ADHD inattentive symptom severity. There was no main effect of birth weight centile on ADHD symptom severity. SNPs within angiogenic (NRP1 & NRP2), neurotrophic (NTRK1 & NTRK3), cytokine (IL16 & S100B), and kynurenine (CCBL1 & CCBL2) genes moderate the association between birth weight centile and ADHD symptom severity. The SNP main effects and SNP × birth weight centile interactions remained significant after adjusting for multiple testing. Genetic variability in angiogenic, neurotrophic, and inflammatory systems may moderate the association between restricted prenatal growth, a proxy for an adverse prenatal environment, and risk to develop ADHD.

AB - Low birth weight is associated with increased risk for Attention-Deficit/Hyperactivity Disorder (ADHD); however, the etiological underpinnings of this relationship remain unclear. This study investigated if genetic variants in angiogenic, dopaminergic, neurotrophic, kynurenine, and cytokine-related biological pathways moderate the relationship between birth weight and ADHD symptom severity. A total of 398 youth from two multi-site, family-based studies of ADHD were included in the analysis. The sample consisted of 360 ADHD probands, 21 affected siblings, and 17 unaffected siblings. A set of 164 SNPs from 31 candidate genes, representing five biological pathways, were included in our analyses. Birth weight and gestational age data were collected from a state birth registry, medical records, and parent report. Generalized Estimating Equations tested for main effects and interactions between individual SNPs and birth weight centile in predicting ADHD symptom severity. SNPs within neurotrophic (NTRK3) and cytokine genes (CNTFR) were associated with ADHD inattentive symptom severity. There was no main effect of birth weight centile on ADHD symptom severity. SNPs within angiogenic (NRP1 & NRP2), neurotrophic (NTRK1 & NTRK3), cytokine (IL16 & S100B), and kynurenine (CCBL1 & CCBL2) genes moderate the association between birth weight centile and ADHD symptom severity. The SNP main effects and SNP × birth weight centile interactions remained significant after adjusting for multiple testing. Genetic variability in angiogenic, neurotrophic, and inflammatory systems may moderate the association between restricted prenatal growth, a proxy for an adverse prenatal environment, and risk to develop ADHD.

U2 - 10.1002/ajmg.b.32275

DO - 10.1002/ajmg.b.32275

M3 - Article

C2 - 25346392

SN - 1552-485X

VL - 165

SP - 691

EP - 704

JO - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

JF - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

IS - 8

ER -

Smith TF, Anastopoulos AD, Garrett ME, Arias-Vasquez A, Franke B, Oades RD et al. Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2014 Dec;165(8):691-704. Epub 2014 Oct 25. doi: 10.1002/ajmg.b.32275

Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity

Abstract

Access to Document

Fingerprint

Cite this