TY - JOUR
T1 - Anhedonia as a Potential Transdiagnostic Phenotype With Immune-Related Changes in Recent-Onset Mental Health Disorders
AU - PRONIA Consortium
AU - Lalousis, Paris Alexandros
AU - Malaviya, Aanya
AU - Khatibi, Ali
AU - Saberi, Majid
AU - Kambeitz-Ilankovic, Lana
AU - Haas, Shalaila S.
AU - Wood, Stephen J.
AU - Barnes, Nicholas M.
AU - Rogers, Jack
AU - Chisholm, Katharine
AU - Bertolino, Alessandro
AU - Borgwardt, Stefan
AU - Brambilla, Paolo
AU - Kambeitz, Joseph
AU - Lencer, Rebekka
AU - Pantelis, Christos
AU - Ruhrmann, Stephan
AU - Salokangas, Raimo K.R.
AU - Schultze-Lutter, Frauke
AU - Schmidt, Andre
AU - Meisenzahl, Eva
AU - Dwyer, Dominic
AU - Koutsouleris, Nikolaos
AU - Upthegrove, Rachel
AU - Griffiths, Siân Lowri
N1 - Publisher Copyright:
© 2024 Society of Biological Psychiatry
PY - 2024/10
Y1 - 2024/10
N2 - Background: Chronic low-grade inflammation is observed across mental disorders and is associated with difficult-to-treat-symptoms of anhedonia and functional brain changes, reflecting a potential transdiagnostic dimension. Previous investigations have focused on distinct illness categories in people with enduring illness, but few have explored inflammatory changes. We sought to identify an inflammatory signal and the associated brain function underlying anhedonia among young people with recent-onset psychosis and recent-onset depression. Methods: Resting-state functional magnetic resonance imaging, inflammatory markers, and anhedonia symptoms were collected from 108 (mean [SD] age = 26.2 [6.2] years; female = 50) participants with recent-onset psychosis (n = 53) and recent-onset depression (n = 55) from the European Union/Seventh Framework Programme–funded PRONIA (Personalised Prognostic Tools for Early Psychosis Management) study. Time series were extracted using the Schaefer atlas, defining 100 cortical regions of interest. Using advanced multimodal machine learning, an inflammatory marker model and a functional connectivity model were developed to classify participants into an anhedonic group or a normal hedonic group. Results: A repeated nested cross-validation model using inflammatory markers classified normal hedonic and anhedonic recent-onset psychosis/recent-onset depression groups with a balanced accuracy of 63.9% and an area under the curve of 0.61. The functional connectivity model produced a balanced accuracy of 55.2% and an area under the curve of 0.57. Anhedonic group assignment was driven by higher levels of interleukin 6, S100B, and interleukin 1 receptor antagonist and lower levels of interferon gamma, in addition to connectivity within the precuneus and posterior cingulate. Conclusions: We identified a potential transdiagnostic anhedonic subtype that was accounted for by an inflammatory profile and functional connectivity. Results have implications for anhedonia as an emerging transdiagnostic target across emerging mental disorders.
AB - Background: Chronic low-grade inflammation is observed across mental disorders and is associated with difficult-to-treat-symptoms of anhedonia and functional brain changes, reflecting a potential transdiagnostic dimension. Previous investigations have focused on distinct illness categories in people with enduring illness, but few have explored inflammatory changes. We sought to identify an inflammatory signal and the associated brain function underlying anhedonia among young people with recent-onset psychosis and recent-onset depression. Methods: Resting-state functional magnetic resonance imaging, inflammatory markers, and anhedonia symptoms were collected from 108 (mean [SD] age = 26.2 [6.2] years; female = 50) participants with recent-onset psychosis (n = 53) and recent-onset depression (n = 55) from the European Union/Seventh Framework Programme–funded PRONIA (Personalised Prognostic Tools for Early Psychosis Management) study. Time series were extracted using the Schaefer atlas, defining 100 cortical regions of interest. Using advanced multimodal machine learning, an inflammatory marker model and a functional connectivity model were developed to classify participants into an anhedonic group or a normal hedonic group. Results: A repeated nested cross-validation model using inflammatory markers classified normal hedonic and anhedonic recent-onset psychosis/recent-onset depression groups with a balanced accuracy of 63.9% and an area under the curve of 0.61. The functional connectivity model produced a balanced accuracy of 55.2% and an area under the curve of 0.57. Anhedonic group assignment was driven by higher levels of interleukin 6, S100B, and interleukin 1 receptor antagonist and lower levels of interferon gamma, in addition to connectivity within the precuneus and posterior cingulate. Conclusions: We identified a potential transdiagnostic anhedonic subtype that was accounted for by an inflammatory profile and functional connectivity. Results have implications for anhedonia as an emerging transdiagnostic target across emerging mental disorders.
KW - Anhedonia
KW - Depression
KW - Inflammation
KW - Prediction
KW - Psychosis
KW - Transdiagnostic
UR - http://www.scopus.com/inward/record.url?scp=85200777221&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2024.05.019
DO - 10.1016/j.biopsych.2024.05.019
M3 - Article
C2 - 38823495
AN - SCOPUS:85200777221
SN - 0006-3223
VL - 96
SP - 615
EP - 622
JO - Biological psychiatry
JF - Biological psychiatry
IS - 7
ER -