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Animal models of migraine and experimental techniques used to examine trigeminal sensory processing

Research output: Contribution to journalReview article

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Animal models of migraine and experimental techniques used to examine trigeminal sensory processing. / Harriott, Andrea M.; Strother, Lauren C.; Vila-Pueyo, Marta; Holland, Philip R.

In: Journal of Headache and Pain, Vol. 20, No. 1, 91, 2019.

Research output: Contribution to journalReview article

Harvard

Harriott, AM, Strother, LC, Vila-Pueyo, M & Holland, PR 2019, 'Animal models of migraine and experimental techniques used to examine trigeminal sensory processing', Journal of Headache and Pain, vol. 20, no. 1, 91. https://doi.org/10.1186/s10194-019-1043-7

APA

Harriott, A. M., Strother, L. C., Vila-Pueyo, M., & Holland, P. R. (2019). Animal models of migraine and experimental techniques used to examine trigeminal sensory processing. Journal of Headache and Pain, 20(1), [91]. https://doi.org/10.1186/s10194-019-1043-7

Vancouver

Harriott AM, Strother LC, Vila-Pueyo M, Holland PR. Animal models of migraine and experimental techniques used to examine trigeminal sensory processing. Journal of Headache and Pain. 2019;20(1). 91. https://doi.org/10.1186/s10194-019-1043-7

Author

Harriott, Andrea M. ; Strother, Lauren C. ; Vila-Pueyo, Marta ; Holland, Philip R. / Animal models of migraine and experimental techniques used to examine trigeminal sensory processing. In: Journal of Headache and Pain. 2019 ; Vol. 20, No. 1.

Bibtex Download

@article{7014310fbb8f4505994a1009f5b77f52,
title = "Animal models of migraine and experimental techniques used to examine trigeminal sensory processing",
abstract = "Background: Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. Main body: Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes. Conclusion: Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.",
keywords = "Animal models, Electrophysiology, Headache, Migraine, Pain, Preclinical, Translation",
author = "Harriott, {Andrea M.} and Strother, {Lauren C.} and Marta Vila-Pueyo and Holland, {Philip R.}",
year = "2019",
doi = "10.1186/s10194-019-1043-7",
language = "English",
volume = "20",
journal = "Journal of Headache and Pain",
issn = "1129-2369",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Animal models of migraine and experimental techniques used to examine trigeminal sensory processing

AU - Harriott, Andrea M.

AU - Strother, Lauren C.

AU - Vila-Pueyo, Marta

AU - Holland, Philip R.

PY - 2019

Y1 - 2019

N2 - Background: Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. Main body: Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes. Conclusion: Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.

AB - Background: Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of its accompanying disability and can encumber almost every aspect of daily life. Main body: Advancements in our understanding of the neurobiology of migraine headache have come in large from basic science research utilizing small animal models of migraine-related pain. In this current review, we aim to describe several commonly utilized preclinical models of migraine. We will discuss the diverse array of methodologies for triggering and measuring migraine-related pain phenotypes and highlight briefly specific advantages and limitations therein. Finally, we will address potential future challenges/opportunities to refine existing and develop novel preclinical models of migraine that move beyond migraine-related pain and expand into alternate migraine-related phenotypes. Conclusion: Several well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders.

KW - Animal models

KW - Electrophysiology

KW - Headache

KW - Migraine

KW - Pain

KW - Preclinical

KW - Translation

UR - http://www.scopus.com/inward/record.url?scp=85071624744&partnerID=8YFLogxK

U2 - 10.1186/s10194-019-1043-7

DO - 10.1186/s10194-019-1043-7

M3 - Review article

C2 - 31464579

AN - SCOPUS:85071624744

VL - 20

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

IS - 1

M1 - 91

ER -

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