Animal models of mucosal Candida infection

J R Naglik, P L Fidel, F C Odds

Research output: Contribution to journalLiterature reviewpeer-review

126 Citations (Scopus)

Abstract

Rodent models of oral, vaginal and gastrointestinal Candida infection are described and discussed in terms of their scientific merits. The common feature of all experimental mucosal Candida infections is the need for some level of host immunocompromise or exogenous treatment to ensure quantitatively reproducible disease. A growing literature describes the contributions of such candidiasis models to our understanding of certain aspects of fungal virulence and host response to mucosal Candida albicans challenge. Evidence to date shows that T-lymphocyte responses dominate host immune defences to oral and gastrointestinal challenge, while other, highly compartmentalized responses defend vaginal surfaces. By contrast the study of C. albicans virulence factors in mucosal infection models has only begun to unravel the complex of attributes required to define the difference between strongly and weakly muco-invasive strains
Original languageEnglish
Pages (from-to)129 - 139
Number of pages11
JournalFems Microbiology Letters
Volume283
Issue number2
DOIs
Publication statusPublished - Jun 2008

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