Ankle Brachial Index (ABI) predicts 2-year mortality risk among older adults in the Republic of Congo: The EPIDEMCA-FU study

Harielle Samba, Maëlenn Guerchet*, Bébène Ndamba-Bandzouzi, Gilles Kehoua, Pascal Mbelesso, Ileana Desormais, Victor Aboyans, Pierre Marie Preux, Philippe Lacroix

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background and aims: Peripheral artery disease (PAD) is known to be associated with mortality in high income countries but no data regarding Sub-Saharan Africa (SSA) populations are documented. This study aimed at assessing the prognostic value of the Ankle Brachial Index (ABI) among older adults in the Republic of Congo. Methods: Congolese subjects ≥65 years were included in a longitudinal population-based survey (EPIDEMCA-FU). Demographic, biological, and clinical data were collected at baseline. PAD was defined by an ABI≤0.90. Information on mortality was collected from key informants in participants' households. Cox proportional hazard models, adjusted for traditional and cardiovascular risk factors, were fitted to evaluate the association between an ABI≤0.90 and death. Results: 1029 participants were recruited at baseline. ABI measurement was obtained from 927 participants, of whom 17.4% presented an ABI≤0.90. During a 2-year follow-up, a total of 83 (9.1%) deaths were recorded. Mortality was higher in the low-ABI group with 23 deaths (14.7%) vs. 57 (7.8%) and 3 (12.0%), respectively among those with 0.90 < ABI<1.4 and ABI≥1.40 (p = 0.039). After adjustment, an ABI≤0.90 was associated with an increased risk of mortality (HR = 1.86; 95%CI 1.04–3.87). Mortality was also independently associated with increasing age (HR = 1.05; 95%CI 1.02–1.09), dementia (HR = 2.73; 95% CI 1.15–8.05), alcohol use (HR = 0.51; 95%CI 0.29–0.88) and female sex (HR = 0.37; 95%CI 0.19–0.72). Conclusions: In this study, a low ABI predicted an increased mortality risk among older people. ABI may represent a simple and inexpensive tool to identify older people at high risk of death in SSA.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalAtherosclerosis
Volume286
Early online date17 May 2019
DOIs
Publication statusPublished - Jul 2019

Keywords

  • Ankle-brachial index
  • Epidemiology
  • Mortality
  • Older adults
  • Peripheral artery disease
  • Sub-Saharan Africa

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