Ankle-Brachial Index: An Ubiquitous Marker of Cognitive Impairment-The EPIDEMCA Study.

Ileana Desormais, Victor Aboyans, Maelenn Guerchet, Bebene Ndamba-Bandzouzi, Pascal Mbelesso, Dania Mohty, Benoit Marin, Jean-Francois Dartigues, Pierre-Marie Preux, Philippe Lacroix, EPIDEMCA Investigators

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Epidemiological research on the implication of atherosclerosis in the development of cognitive impairment is lacking in low- and middle-income countries, where two-thirds of the individuals affected by dementia live. Individuals aged ≥65 years living in urban and rural areas of 2 countries in Central Africa were invited. Demographic, clinical, and biological data were collected, and the ankle-brachial index (ABI) was measured. Cognitive impairment was defined according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria. Among 1662 participants (age 72.9 years, 59.3% females), the prevalence of cognitive impairment was 13.6%, which is higher in individuals with ABI ≤ 0.90 and ABI ≥ 1.40 than those with 0.90 < ABI < 1.40 (20.1% and 17% vs 12%, P = .0024). Cognitive impairment was significantly associated with the factors such as age (odds ratio [OR]: 1.09; 95% confidence interval [CI]: 1.07-1.12, P < .0001), female gender (OR: 2.36, 95% CI: 1.59-3.49, P < .0001), smoking (OR: 1.54, 95% CI: 1.06-2.23, P = .0026), and low ABI (≤0.90; OR: 1.52, 95% CI: 1.03-2.25, P = .0359). The ABI, a ubiquitous marker of atherosclerosis, provides independent and incremental information on susceptibility to present with cognitive disorders.
Original languageEnglish
Pages (from-to)497-506
Issue number6
Early online date2 Nov 2017
Publication statusPublished - 1 Jul 2018


  • Africa
  • Ankle-Brachial Index
  • Atherosclerosis
  • Elderly


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