King's College London

Research portal

Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner

Research output: Contribution to journalArticle

Standard

Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner. / Miller, Suzanne L; Sutherland, Amy E; Supramaniam, Veena G; Walker, David W; Jenkin, Graham; Wallace, Euan M.

In: Reproduction Fertility and Development, Vol. 24, No. 5, 2012, p. 753-758.

Research output: Contribution to journalArticle

Harvard

Miller, SL, Sutherland, AE, Supramaniam, VG, Walker, DW, Jenkin, G & Wallace, EM 2012, 'Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner', Reproduction Fertility and Development, vol. 24, no. 5, pp. 753-758. https://doi.org/10.1071/RD11143

APA

Miller, S. L., Sutherland, A. E., Supramaniam, V. G., Walker, D. W., Jenkin, G., & Wallace, E. M. (2012). Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner. Reproduction Fertility and Development, 24(5), 753-758. https://doi.org/10.1071/RD11143

Vancouver

Miller SL, Sutherland AE, Supramaniam VG, Walker DW, Jenkin G, Wallace EM. Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner. Reproduction Fertility and Development. 2012;24(5):753-758. https://doi.org/10.1071/RD11143

Author

Miller, Suzanne L ; Sutherland, Amy E ; Supramaniam, Veena G ; Walker, David W ; Jenkin, Graham ; Wallace, Euan M. / Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner. In: Reproduction Fertility and Development. 2012 ; Vol. 24, No. 5. pp. 753-758.

Bibtex Download

@article{8baab98fc52e4a8d8590dff807c2a4c4,
title = "Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner",
abstract = "Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5±4.4% (P=0.002) and 21.7±6.0% (P=0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3±2.8% and 20.5±3.6% in control male and female fetuses, respectively; and by 22.9±3.1% and 38.3±3.4% in IUGR male and female fetuses, respectively; P",
author = "Miller, {Suzanne L} and Sutherland, {Amy E} and Supramaniam, {Veena G} and Walker, {David W} and Graham Jenkin and Wallace, {Euan M}",
year = "2012",
doi = "10.1071/RD11143",
language = "English",
volume = "24",
pages = "753--758",
journal = "Reproduction Fertility and Development",
issn = "1031-3613",
publisher = "CSIRO",
number = "5",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner

AU - Miller, Suzanne L

AU - Sutherland, Amy E

AU - Supramaniam, Veena G

AU - Walker, David W

AU - Jenkin, Graham

AU - Wallace, Euan M

PY - 2012

Y1 - 2012

N2 - Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5±4.4% (P=0.002) and 21.7±6.0% (P=0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3±2.8% and 20.5±3.6% in control male and female fetuses, respectively; and by 22.9±3.1% and 38.3±3.4% in IUGR male and female fetuses, respectively; P

AB - Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5±4.4% (P=0.002) and 21.7±6.0% (P=0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3±2.8% and 20.5±3.6% in control male and female fetuses, respectively; and by 22.9±3.1% and 38.3±3.4% in IUGR male and female fetuses, respectively; P

U2 - 10.1071/RD11143

DO - 10.1071/RD11143

M3 - Article

C2 - 22697125

VL - 24

SP - 753

EP - 758

JO - Reproduction Fertility and Development

JF - Reproduction Fertility and Development

SN - 1031-3613

IS - 5

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454