Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) - A systems neuroscience approach to common developmental disorders

Mark H. Johnson; Tony Charman; Andrew Pickles; Emily J H Jones

Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) - A systems neuroscience approach to common developmental disorders

Mark H. Johnson, Tony Charman, Andrew Pickles, Emily J H Jones

Birkbeck, University of London

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Abstract

We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.

Original language	English
Journal	Journal of Child Psychology and Psychiatry
Publication status	Accepted/In press - 25 Nov 2020

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title = "Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) - A systems neuroscience approach to common developmental disorders",

abstract = "We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.",

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AU - Pickles, Andrew

AU - Jones, Emily J H

PY - 2020/11/25

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N2 - We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.

AB - We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.

M3 - Article

SN - 0021-9630

JO - Journal of Child Psychology and Psychiatry

JF - Journal of Child Psychology and Psychiatry

ER -

Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) - A systems neuroscience approach to common developmental disorders

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