Abstract
Infection is often a complication following joint replacement surgery and the use of antibiotic-impregnated cements is emerging to be a potentially effective clinical procedure that may assist in reducing the incidence of deep infection. The main advantage of local antibiotic delivery is the ability to achieve high levels of antibiotic at the target site without increasing systemic toxicity whilst providing sustained release over prolonged periods of time. Although antibiotic-loaded bone cements have been in use in Europe for over 30 years, they were approved by the US Food and Drug Administration (FDA) in 2003 and are now being increasingly used as a local drug delivery system. The present chapter examines the literature and discusses the effect of antibiotics on the physico-mechanical properties of cements and their clinical efficacy.
| Original language | English |
|---|---|
| Title of host publication | Orthopaedic Bone Cements |
| Publisher | Elsevier Science Ltd |
| Pages | 313-331 |
| Number of pages | 19 |
| ISBN (Print) | 9781845693763 |
| DOIs | |
| Publication status | Published - Oct 2008 |