Antibodies to prothrombin

M L Bertolaccini

doi:10.1177/0961203312443299

Antibodies to prothrombin

M L Bertolaccini

Women & Children's Health

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with phosphatidylserine (aPS/PT). Although aPT and/or aPS/PT are associated with antiphospholipid syndrome (APS) -related clinical features and these antibodies correlate with each other, aPT and aPS/PT belong to different populations of autoantibodies even though they can both be present in the same patient. Early studies suggested that these antibodies might be the antigenic target of lupus anticoagulant (LA) and their correlation and clinical significance is being investigated.

Original language	English
Article number	N/A
Pages (from-to)	729-731
Number of pages	3
Journal	Lupus
Volume	21
Issue number	7
DOIs	https://doi.org/10.1177/0961203312443299
Publication status	Published - Jun 2012

Keywords

Autoantibodies
Humans
Lupus Coagulation Inhibitor
Prothrombin

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abstract = "Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with phosphatidylserine (aPS/PT). Although aPT and/or aPS/PT are associated with antiphospholipid syndrome (APS) -related clinical features and these antibodies correlate with each other, aPT and aPS/PT belong to different populations of autoantibodies even though they can both be present in the same patient. Early studies suggested that these antibodies might be the antigenic target of lupus anticoagulant (LA) and their correlation and clinical significance is being investigated.",

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AB - Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with phosphatidylserine (aPS/PT). Although aPT and/or aPS/PT are associated with antiphospholipid syndrome (APS) -related clinical features and these antibodies correlate with each other, aPT and aPS/PT belong to different populations of autoantibodies even though they can both be present in the same patient. Early studies suggested that these antibodies might be the antigenic target of lupus anticoagulant (LA) and their correlation and clinical significance is being investigated.

KW - Autoantibodies

KW - Humans

KW - Lupus Coagulation Inhibitor

KW - Prothrombin

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DO - 10.1177/0961203312443299

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SN - 0961-2033

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SP - 729

EP - 731

JO - Lupus

JF - Lupus

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ER -

Antibodies to prothrombin

Abstract

Keywords

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