Antibody radiolabeling techniques to optimize cellular retention

Stephen J. Archibald

doi:10.1021/jm401794v

Antibody radiolabeling techniques to optimize cellular retention

Stephen J. Archibald^*

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Radiolabeling of antibodies and antibody fragments facilitates the development of new targeted therapeutics or tracking and validation of biosimilars. The typical metal ion chelators that can be used for radiolabeling reactions have residualizing properties in tissues/tumors. A team at Genentech has developed an elegant new technique for combining iodine radiolabeling with an azamacrocyclic chelator to confer residualizing properties on the radioiodine metabolites. Robust protocols, such as this example, are required for the future development of protein based drugs.

Original language	English
Pages (from-to)	9415-9417
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	56
Issue number	23
DOIs	https://doi.org/10.1021/jm401794v
Publication status	Published - 12 Dec 2013

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AB - Radiolabeling of antibodies and antibody fragments facilitates the development of new targeted therapeutics or tracking and validation of biosimilars. The typical metal ion chelators that can be used for radiolabeling reactions have residualizing properties in tissues/tumors. A team at Genentech has developed an elegant new technique for combining iodine radiolabeling with an azamacrocyclic chelator to confer residualizing properties on the radioiodine metabolites. Robust protocols, such as this example, are required for the future development of protein based drugs.

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Antibody radiolabeling techniques to optimize cellular retention

Abstract

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